YWHAQ
14-3-3 protein theta is a protein that in humans is encoded by the YWHAQ gene.Function
This gene product belongs to the 14-3-3 family of proteins that mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence that is polymorphic; however, there is no correlation between the repeat number and the disease.Interactions
YWHAQ has been shown to interact with:
- BAX,
- BAD,
- C-Raf,
- CRTC2,
- CBL
- HDAC5,
- MEF2D,
- NRIP1,
- PFKFB2,
- PRKD1,
- PRKCZ,
- TERT, and
- UCP3.
