He entered Middle Temple in 1632. During the Civil War he kept out of the conflict and in 1644 he went abroad. He was on very bad terms with his father but in about 1654 his father had to make over the estate at Newnham to him. In April 1660, Strode was elected Member of Parliament for Plympton Erle for the Convention Parliament. He became JP for Devon in July 1660 and became a commissioner for assessment in August 1660. He took little part in parliament but on 6 November 1660 he proposed a message of congratulation to the Queen Mother when she returned from France. He was knighted on 5 December 1660. In 1661 Strode was re-elected MP for Plympton Erle for the Cavalier Parliament and sat until his death in 1676. He was a commissioner for corporations from 1662 to 1663 and was recorder of Plympton Erle from around 1663 until his death. He was a commissioner for recusants for Devon in 1675.
Marriages and children
Strode married twice:
Firstly on 25 November 1636 to Anne Button, daughter of Sir William Button of Parkgate, Tawstock, Devon, by whom he had a son and three daughters including:
*Richard Strode, MP for Plympton Erle. He died unmarried. Together with his near neighbour Sir George Treby of Plympton House, Lord Chief Justice of the Common Pleas, also an MP for Plympton Erle, he financed the building of Plympton Guildhall which he gave to the Borough of Plympton.
Secondly on 19 October 1647 he married Blanche Kekewich, daughter of William Kekewich of Catchfrench, Cornwall by whom he had seven sons and one daughter, including:
*William Strode, 2nd son, inherited Newnham from his elder half-brother Richard Strode. He died without children.
*Francis Strode, 3rd son
*Sidney I Strode, 4th son, married a certain Thomasine by whom he had an eldest son and heir Sidney II Strode, of Newnham, who inherited from his uncle William Strode the ancient Strode seat of Newnham and built for himself a new seat nearby on the estate at Loughtor, which he named "Newnham Park".
*John Strode, 5th son, died an infant
*Charles Strode, 6th son, married a certain Mary and had a daughter Jane Strode
*Jane Strode, died an infant
Death and burial
He died at the age of 61 and was buried at Plympton St Mary.