Waynesburg was platted in 1814, and named in honor of Anthony Wayne. A post office called Waynesburgh was established in 1824, and the name was changed to Waynesburg in 1893.
As of the census of 2010, there were 923 people, 361 households, and 249 families living in the village. The population density was. There were 408 housing units at an average density of. The racial makeup of the village was 97.6% White, 1.0% African American, 0.1% Native American, 0.1% Asian, and 1.2% from two or more races. Hispanic or Latino of any race were 0.7% of the population. There were 361 households of which 33.8% had children under the age of 18 living with them, 47.1% were married couplesliving together, 16.9% had a female householder with no husband present, 5.0% had a male householder with no wife present, and 31.0% were non-families. 28.5% of all households were made up of individuals and 14.7% had someone living alone who was 65 years of age or older. The average household size was 2.56 and the average family size was 3.10. The median age in the village was 39 years. 25.7% of residents were under the age of 18; 8.2% were between the ages of 18 and 24; 24.4% were from 25 to 44; 28.1% were from 45 to 64; and 13.5% were 65 years of age or older. The gender makeup of the village was 50.2% male and 49.8% female.
2000 census
As of the census of 2000, there were 1,003 people, 391 households, and 276 families living in the village. The population density was 1,944.5 people per square mile. There were 410 housing units at an average density of 794.9 per square mile. The racial makeup of the village was 95.71% White, 2.89% African American, 0.30% Native American, 0.20% Asian, and 0.90% from two or more races. Hispanic or Latino of any race were 1.00% of the population. There were 391 households out of which 35.0% had children under the age of 18 living with them, 50.4% were married couples living together, 15.3% had a female householder with no husband present, and 29.4% were non-families. 25.8% of all households were made up of individuals and 14.8% had someone living alone who was 65 years of age or older. The average household size was 2.57 and the average family size was 3.09. In the village, the population was spread out with 27.2% under the age of 18, 7.1% from 18 to 24, 28.7% from 25 to 44, 20.6% from 45 to 64, and 16.4% who were 65 years of age or older. The median age was 36 years. For every 100 females there were 97.1 males. For every 100 females age 18 and over, there were 93.1 males. The median income for a household in the village was $34,125, and the median income for a family was $39,861. Males had a median income of $34,792 versus $19,779 for females. The per capita income for the village was $14,996. About 13.2% of families and 16.4% of the population were below the poverty line, including 24.2% of those under age 18 and 4.5% of those age 65 or over.
