A UFC Middleweight Championshipbout between the current champion Israel Adesanya and former interim title challenger Yoel Romero headlined the event. A UFC Women's Strawweight Championship bout between the current champion Zhang Weili and former champion Joanna Jędrzejczyk took place as the co-main event. A middleweight bout between former champion Robert Whittaker and Jared Cannonier was expected to take place at this event. However, it was announced on January 15 that Whittaker pulled out of the bout. Subsequently, promotion officials announced that Cannonier would be on standby in the event that one of the main eventparticipants were to pull out of that contest. In turn, Cannonier indicated in mid-February that he had suffered a torn pectoral injury while training and would be sidelined for several months. The pairing is now scheduled for UFC 254 A bantamweight bout between Sean O'Malley and bantamweight winner José Alberto Quiñónez was originally scheduled to take place at UFC 229. However, it was scrapped after O'Malley failed a United States Anti-Doping Agencydrug test. The bout was then expected to take place at UFC 247, but it was eventually moved to this event for unknown reasons. While not officially announced by the organization, a featherweight bout between Calvin Kattar and Jeremy Stephens was expected to take place at the event. However, Stephens was removed from the card in mid-January with an injury. The pairing was left intact and rescheduled for UFC 249. A featherweight bout between Douglas Silva de Andrade and Movsar Evloev was scheduled to take place at the event. However, de Andrade withdrew from the bout due to injury and was replaced by promotional newcomer Jamall Emmers. Subsequently, Evloev pulled out of the fight in late February citing injuries sustained in a road accident. He was replaced by Giga Chikadze. A middleweight bout between Derek Brunson and Edmen Shahbazyan was scheduled to take place at the event. However, it was announced on February 20 that the bout had moved to. At the weigh-ins, Emily Whitmire weighed in at 117.5 pounds, 1.5 pounds over the strawweight non-title fight limit of 116 pounds. She was fined 20% of her purse and her bout with Polyana Viana was expected to proceed as scheduled at a catchweight. However, Whitmire was hospitalized the day of the event and the fight was cancelled.
Results
Bonus awards
The following fighters received $50,000 bonuses.
Fight of the Night: Zhang Weili vs. Joanna Jędrzejczyk
Performance of the Night: Beneil Dariush and Sean O’Malley
Reported payout
The following is the reported payout to the fighters as reported to the Nevada State Athletic Commission. It does not include sponsor money and also does not include the UFC's traditional "fight night" bonuses. The total disclosed payout for the event was $2,086,000.
Israel Adesanya: $500,000 def. Yoel Romero: $350,000
