US 10 enters the state and Pierce County from Minnesota at Prescott and immediately joins with WIS 35 north. WIS 35 turns north northeast at WIS 29 while US 10 continues east and passes through Ellsworth at the junctions with WIS 65 and US 63 The highway turns southeast and passes through Ono and Plum City. US 10 then enters Pepin County and junctions with WIS 25 and WIS 85 at Durand US 10 briefly enters Buffalo County and passes through Mondovi at the junction with WIS 37. In northern Trempealeau County, the highway crosses WIS 93 at Eleva, passes through Strum, and junctions with US 53 and I-94 in Osseo. The route then enters Jackson County where it joins US 12 and WIS 27. US 12 and WIS 27 split to the south at the Clark County line while US 10 continues east to Neillsville and crosses WIS 73 there. The highway then meanders northeast into Wood County, intersecting with WIS 80. US 10 becomes an expressway at this intersection, and continues as an expressway until the Wood–Portage county line. The highway then passes south of Marshfield, meeting WIS 13 south of Marshfield at a diamond interchange. US 10 then passes south of Auburndale and enters Portage County near Milladore. US 10 enters Portage County as a freeway, and meets WIS 34 and WIS 13 south west of Junction City. WIS 34 splits to the north east of Junction City while US 10 turns east and bypasses Stevens Point. The highway then meets I-39/US 51 north of the city and runs concurrently with I-39/US 51 for about before exiting to the east of Stevens Point. At this point, US 10 becomes a multilane surface road for about six miles, then becomes an expressway and heads southeast, passing through Amherst and crossing into Waupaca County. US 10 bypasses the city of Waupaca to the south and junctions with WIS 22, WIS 54 and meets WIS 49 south. US 10 and WIS 49 turn eastward to Weyauwega then head south to Fremont where WIS 49 turns south and US 10 becomes a freeway at the junction with WIS 110. US 10 collects US 45 south in northwest Winnebago County for a southeast trek before US 45 splits to the south and US 10 turns east to rendezvous with WIS 441 at the junction with I-41/US 41 in Neenah. US 10 turns south off the WIS 441 freeway south of Appleton and turns east into Calumet County. As a multilane urban arterial, US 10 collects WIS 114 for before the latter splits southward before US 10 junctions with WIS 55. The highway then crosses WIS 32 and WIS 57 at Forest Junction and turns southeast to pass through Brillion and into Manitowoc County. The highway passes through Reedsville and Whitelaw before turning south onto I-43 for and turning east off the Interstate to head along WIS 42 into the north side of Manitowoc. US 10 then turns south into downtown where it continues into Michigan via the carferry to Ludington. The Badger only operates on a seasonal basis from May to October.
History
Prior to 1926, what is now US 10 was State Trunk Highway 18. However, Highway 18 initially only ran from Humbird, near where US 10 and U.S. Highway 12 cross, east to Manitowoc. State Trunk Highway 34 ran from Prescott to Highway 37 in Mondovi. The route between Mondovi and Humbird was not numbered until the early 1920s, when Highway 18 was extended west from Humbird past Mondovi to Prescott, eliminating Highway 34. When US 10 was designated in late 1926, it ran along U.S. Highway 12 from Minnesota east to Humbird, splitting there to run to Manitowoc. The piece of former Highway 18 west of Humbird became Highway 34, as the number 18 conflicted with U.S. Highway 18. In 1934, Highway 34 disappeared again, as US 10 was separated from the US 12 concurrency to run along it. At their spring meeting in 2015, the American Association of State Highway and Transportation Officials committee extended US 10 to include the route of the SS Badger between Ludington and Manitowoc.
