Timothy A. Springer


Timothy "Tim" A. Springer, Ph.D. is an immunologist and Latham Family Professor at Harvard Medical School. Springer is best known for his pioneering work in discovering the first integrins and intercellular adhesion molecules and elucidating how these cell adhesion molecules function in the immune system. His innovative use of monoclonal antibodies in his research paved the way for the development of therapeutic antibodies, known as selective adhesion molecule inhibitors, to treat autoimmune diseases. In recent years, Springer's research interest has expanded to include malaria, transforming growth factor beta signaling molecules, and von Willebrand factor.

Education and training

Springer attended the University of California, Berkeley where he majored in Biochemistry. After graduating Phi Beta Kappa with Distinction and the Departmental Citation, he went on to do his Ph.D. in the lab of Jack Strominger at Harvard University. Following his graduate work, Springer received his postdoctoral training under the guidance of César Milstein at the University of Cambridge.

Research focus

His lab elucidated different steps in the homing process of lymphocytes with a special focus on the integrin LFA-1. His research encompasses the cell adhesion molecules and chemotactic signals involved in lymphocyte migration in health and disease.

Business career

When Moderna Therapeutics launched its IPO in December 2018, Springer became the company's fourth-largest shareholder and made $400 million, after investing $5 million in the startup early on. Earlier, he had made around $100 million on his first venture LeukoSite, which in 1999 had been bought by Millennium Pharmaceuticals. Springer is also a founder of biotechnology companies Morphic Therapeutic and Scholar Rock. He is also a main investor in Selecta Biosciences. During the coronavirus pandemic crisis, Springer became a billionaire boosting his net worth to more than $1 billion after shares of biotech surge. He has a stake in Moderna Inc, the U.S biotech firm attempting to develop a vaccine for the coronavirus.

Philanthropy

In 2017, Springer co-founded the Institute for Protein Innovation, a 501 nonprofit organization. Springer donated a $10 million foundational grant to the IPI.

Awards