Born in Lincoln, Nebraska, White debuted in her family's circus show at age 2, acting as a "living doll" who would stand in place until she got a cue to begin cooing and wriggling. At the age of 10 she was dancing in vaudeville as part of The White Sisters, leading to jobs with the Ziegfeld Follies and Earl Carroll revue before she moved to Hollywood in the late 1920s. Her first film was A Night in a Dormitory co-starring Ginger Rogers. That job led to a number of short films at Pathé Exchange, where she played leading lady to some of the most familiar comic faces of the day, such as Edgar Kennedy and Leon Errol. White's most famous role arrived in Tell Your Children better known today as Reefer Madness, a low-budget exploitation film to warn audiences of the dangers of marijuana. White appeared as Mae, the oft-ignored voice of conscience to her dope-dealer boyfriend Jack. Jack encourages high school students to take a toke of marijuana, after which they become involved in rape, prostitution, suicide, and various other traumas. The ephemeral film vanished into the vaults for over 30 years. White continued to struggle through B-movies and small roles for the next few years, and in Hollywood circles was more known for her private life than any on-camera abilities. She was married three times, first to radio star Claude Stroud for five years, then a brief marriage to Max Hoffman, Jr. Her final marriage, to actor and costume designer Tony Millard, lasted for several decades. Tell Your Children was found in a vault in 1972 and rechristened Reefer Madness by pro-marijuana activists and a young movie distributor who saw the movie as having great comedic appeal. The film gained a following on college campuses for its campy nature as well as its crazed depiction of marijuana use. White, who had starred with W. C. Fields and Jack Benny in her best years, was somewhat chagrined to be known for such a film. In 1987, she told the Los Angeles Times, "I'm ashamed to say that it's the only one of my films that's become a classic."
Entertaining troops
During World War II, White joined United Servicemen Overseas, a government program which featured entertainment for troops serving overseas, and performed as the leader of an all female swing band called Thelma White and Her All Girl Orchestra. She and her band went to Alaska on several occasions with Rose Hobart and Carmen Miranda. She continued to make appearances in B-movies such as The Bowery Boysfilm series, but near the end of the war contracted a crippling disease while appearing in the Aleutian Islands. White was bedridden for five years and told she would never walk again. Although she did partially recover and appeared in a few late 1940s films, her acting career was essentially over. Together with her band, she released the most famous hit Shoo Shoo Ya Mama in January 1946. White later worked as an agent, representing such actors as Robert Blake and James Coburn.