TREX1
Three prime repair exonuclease 1 is an enzyme that in humans is encoded by the TREX1 gene.Function
This gene encodes the major 3'->5' DNA exonuclease in human cells. The protein is a non-processive exonuclease that may serve a proofreading function for a human DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3' ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, RVCL, and Cree encephalitis. Multiple transcript variants encoding different isoforms have been found for this gene.Clinical relevance
TREX1 helps HIV‑1 to evade cytosolic sensing by degrading viral cDNA in the cytoplasm
