After graduating as doctor of canon and civil law at the University of Bologna on 8 June 1534, he returned to Cracow and became secretary in the royal chancery. On the death of Bishop Tomicki, he continued as secretary under the new vice-chancellor, Bishop Jan Chojeński of Płock. After the death of Bishop Choinski in 1538, Hosius was appointed royal secretary. In that position, he had the entire confidence of King Sigismund, who bestowed various ecclesiastical benefices upon him as reward for his faithful services. In 1543, Hosius was ordained priest. King Sigismund died in 1548, but before his death, he had instructed his son and successor, Sigismund II, to nominate Hosius for the next vacant episcopal see. Hosius was nominated for the See of Chełmno in 1549. He had not sought thatbdignity and accepted it only with reluctance. Hosius was then sent by Sigismund on a diplomatic important mission to the courts of King Ferdinand I at Prague and Emperor Charles V at Brussels and Ghent. The mission resulted in an alliance between Poland and the other monarchies. Upon his return to Poland, he received episcopal consecration at Kraków on 23 March 1550, and he immediately took possession of his see. Hosius had Jesuit sympathies and actively opposed the Protestant Reformation. Two years later, he became Prince-Bishop of Warmia in Royal Prussia, Poland. Hosius drew up the Confessio fidei christiana catholica, adopted by the Synod of Piotrków in 1557. He was a supremely-skillful diplomat and administrator. Hosius and Marcin Kromer were the two bishops most instrumental in keeping the Warmia region Caholic, and neighbouring Ducal Prussia became Protestant. In 1558 Pope Paul IV summoned him to Rome, and soon Hosius became an influential member of the Roman Curia. The following year, Pope Pius IV appointed Hosius as his personal nuncio to Ferdinand I, Holy Roman Emperor, at the court in Vienna, where he was to work on the reopening of the Council of Trent. He was further charged with gaining the support of the emperor's son, Maximilian, who appeared to have Protestant sympathies. For his successful work Hosius was promoted to cardinal in 1561. Pope Pius IV named him Legate-Theologian for the third session of the Council of Trent; the other two legates were Cardinals Puteo and Gonzaga. Despite health issues he mediated between the various factions at the Council and addressed issue particular to Poland-Lithuania, such as the status of the Teutonic Knights and the marriage of Stansilaus Orzechowski. When the Council ended, he returned home, despite requests to travel to Rome for the papal conclave that was to be held after the death of the ailing Pius IV. Cardinal Truchess even suggested thag Hosius was a candidate for the papacy. Instead of going to Rome, he returned to his diocese, leaving Trent on December 1563 to implement the decrees and canons of the Council of Trent. In 1566, Pope Pius V consecrated him as Papal Legate to Poland.
Death and legacy
Besides carrying through many difficult negotiations, he founded the lyceum of Braniewo to counter the rapidly spreading Protestants. It became the centre of the Roman Catholic mission among Protestants. In 1572, Pope Gregory XIII declared Hosius a member of the Congregatio Germania. He died at Capranica Prenestina], near Rome, on 5 August 1579. A special friend to Hosius was Saint Peter Canisius. Both Kromer and Hosius left many records of their German speeches and sermons in their years of duty in the Bishopric of Warmia. They were later translated to Czech, English, and French. A collected edition of his works was published at Cologne, Germany in 1584.
Cause of beatification
The cause of sainthood commenced but paused for a while until it resumed as of 5 August 2006. He is now known as a Servant of God.