Howe was returned unopposed as Member of Parliament for Hindon at the general elections in February and August 1679 and sat until January 1681. He was returned unopposed as MP for Tamworth in 1685 and sat until 1687. Howe held an estate at Chedworth, six miles from Cirencester, and at the 1690 English general election he was returned in a contest as MP for Cirencester on his own interest. He retained the seat at the 1695 English general election. He refused to sign the Association in February 1696, and opposed fixing the price of guineas at 22 shillings in March. He voted against the attainder of Sir John Fenwick on 25 November 1696. Shortly after, he was removed from the Gloucestershire commission of the peace for not signing the Association. He planned to stand for Wiltshire at the 1698 English general election, but was unable to garner enough support. However, he was returned unopposed for Wiltshire at the first general election of 1701 and then defeated in a contest at the second general election of 1701. He was returned as MP for Wiltshire at the 1702 English general election. He succeeded On the death of his father on 1 May 1703, he succeeded to the baronetcy. He voted for the Tack on 28 November 1704. At the 1705 English general election, he was returned again for Wiltshire, and voted against the Court candidate for Speaker on 25 October 1705. He was returned as a Tory at the 1708 British general election, and was appointed to the drafting committee on a bill to prevent bribery at elections on 17 January 1709. He was busy sorting out the complicated affairs of Sir Humphrey Mackworth's Company of Mine Adventurers and in raising the complaints of its proprietors and creditors in Parliament. He voted against the impeachment of Dr Sacheverell in 1710. At the 1710 British general election, he was returned again as a Tory for Wiltshire, and was listed as a 'worthy patriot' who helped detect the mismanagements of the previous administration, and a 'Tory patriot' who opposed to the continuance of war. He was appointed to prepare a bill to restructure the Company of Mine Adventurers on 6 April 1711. He was returned again for Wiltshire at the 1713 British general election, and supported the French Commerce bill. In 1714, he promoted a bill for the repair of several Wiltshire highways. Howe was returned for Wiltshire in 1715 and 1722 and consistently opposed the Whig administrations. He did not stand at the 1727 British general election.
Death and legacy
Howe died on 3 July 1730 and was buried at Great Wishford. He had no children and left his main estates in Wiltshire and Gloucestershire to his cousin John Howe, 1st Baron Chedworth of Somerset.