In 1951, aged 33, Gottlieb joined the Central Intelligence Agency. As a poison expert, he headed the chemical division of the Technical Services Staff. Gottlieb became known as the "Black Sorcerer" and the "Dirty Trickster." He supervised preparations of lethal poisons and drug experiments in mind control. In April 1953 Gottlieb became head of the secret Project MKUltra, which was activated on the order of CIA director Allen Dulles. In this capacity, he administered LSD and other hallucinogenic drugs to unwitting subjects and financed psychiatric research and development of "techniques that would crush the human psyche to the point that it would admit anything". He sponsored physicians such as Ewen Cameron and Harris Isbell in controversial psychiatric research including nonconsensual human experiments.; he was also been named as the individual who gave LSD to Army bacteriologist Frank Olson leading to his death. Gottlieb was the liaison to the military subcontractor Lockheed, then working for the CIA on Project AQUATONE, which would later be known as the U-2 spy plane. In 1953 he procured a safe house for the Lockheed Aeronautics Services Division with an easy and exclusive egress. By 1955 Project MKUltra had grown so large that more government funding was needed. At this point was merely a funding subproject that combined all previous subprojects, including those involving LSD, magic and John Mulholland's The Official CIA Manual of Trickery and Deception, and the procurement of more LSD, but it continued on to include almost 150 known and documented subprojects, including a microwave gun and the search for alternatives to LSD, which led to later programs like Project MKCHICKWIT, most of which focused on South America. In addition to working with subcontractors like Lockheed, the CIA also worked with other branches of the government, the Advanced Research Projects Agency of the Department of Defense and the Office of Naval Intelligence, though it is unclear what role Gottlieb played in these affairs other than authorizing them. 1960s
In March 1960, under The Cuban Project, a CIA plan approved by President Eisenhower—and under the direction of CIA Directorate for Plans Richard M. Bissell—Gottlieb proposed spraying Fidel Castro's television studio with LSD and saturating Castro's shoes with thallium to make his beard fall out. Gottlieb also hatched schemes to assassinate Castro, including the use of a poisoned cigar, a poisoned wetsuit, an exploding conch shell, and a poisonous fountain pen. Gottlieb also played a role in the CIA's attempt to assassinate Prime Minister Patrice Lumumba of the Congo; he took a vial of poison to the Congo with plans to place it on Lumumba's toothbrush in the summer of 1960. He transported these "toxic biological materials" to Larry Devlin, the CIA station chief in the Congo, and although Devlin declined the assignment, a military coup soon overthrew and killed Lumumba. Gottlieb also wanted Iraqi General Abdul Karim Qassim's handkerchief to be contaminated with botulinum.
Final years
Gottlieb retired from the CIA in 1972, saying that he did not believe his work had been effective. Visited in retirement by the son of his late colleague Frank Olson, he was residing in an "ecologically correct" home in Culpeper, Virginia, where he raised goats, ate yogurt and advocated peace and environmentalism. He and his wife spent 18 months running a leper hospital in India. He had two sons and two daughters. On October 7, 1975, Gottlieb testified before the Church Committee under the alias "Joseph Scheider". On March 7, 1999, Gottlieb died at his home in Washington, Virginia. He was reported to have a history of heart problems, but his wife declined to give the cause of death.