Semicarbazone
In organic chemistry, a semicarbazone is a derivative of imines formed by a condensation reaction between a ketone or aldehyde and semicarbazide. They are classified as imine derivatives because they are formed from the reaction of an aldehyde or ketone with the terminal -NH2 group of semicarbazide, which behaves very similarly to primary amines.Formation
;For ketones
;For aldehydes
For example, the semicarbazone of acetone would have the structure 2C=NNHCNH2.Some semicarbazones, such as nitrofurazone, and thiosemicarbazones are known to have anti-viral and anti-cancer activity, usually mediated through binding to copper or iron in cells. Many semicarbazones are crystalline solids, useful for the identification of the parent aldehydes/ketones by melting point analysis.
A thiosemicarbazone is an analog of a semicarbazone which contains a sulfur atom in place of the oxygen atom.
