Ebanks made her debut in February 2001 at the fall show for Tuleh, and has walked the runway for designers including Betsey Johnson, Catherine Malandrino, Pamella Roland and Tommy Hilfiger. She has appeared in campaigns for Abercrombie & Fitch, Tommy Hilfiger and DKNY, and signed a contract with Victoria's Secret in 2005. Ebanks first modeled for Victoria's Secret for their Ipex Bra line, before being signed as an Angel. She and Izabel Goulart made their major débuts in the 2005 Victoria's Secret Fashion Show, working as an Angel until 2008. In 2005, Tyra Banks said she was proud of Ebanks to be representing black women at Victoria's Secret. In 2007, Ebanks was selected to wear the "Very Sexy" Holiday Fantasy Bra Set with a price tag of $4,500,000 dollars that contains diamonds, emeralds, rubies and yellow sapphires—which she wore in the Victoria's Secret "Christmas Dreams and Fantasies 2007" catalogue. She also wore the fantasy bra set during the Victoria's Secret fashion show on 4 December 2007. Ebanks made a special guest appearance on How I Met Your Mother on 26 November 2007 with her fellow Victoria's Secret supermodels. According to Forbes, Ebanks was the twelfth highest paid model of 2008, earning an estimated $2.7 million. Ebanks has graced the covers of Maxim, British GQ and Russian FHM and appeared in editorials for Marie Claire, Glamour, V, German and Italian Elle, Vanidades and Sports Illustrated's 2007 Swimsuit Issue.
Other ventures
Ebanks appeared on the third season of Celebrity Apprentice, but was fired in week 5 on 11 April 2010, placing 9th. Previously, she recorded music and appeared on the UPN-series South Beach. She is featured in The-Dream's music video for the single "Make Up Bag", as well as Kanye West's 2010 short film Runaway, playing a fallen phoenix with whom West's character falls in love. She is now a reoccurring character in BET's Husband's of Hollywood where she plays the love interest of comedian Kevin Hart. Ebanks also appeared in a commercial for State Farm Insurance alongside actor/model Mehcad Brooks. Ebanks also has her own line of swimwear, accessories and shoes called Sass which stands for Selita's Accessories Shoes and Swimwear. The line was seen on the BET Rip The Runway 2012 which she hosted alongside Pooch Hall. Selita Ebanks was to star in the ABC Family TV series called "Nicki" based on the life of music sensation Nicki Minaj alongside Ariana Neal, Wesley Jonathan and McCarrie McCausland. Whoopi Goldberg and J.B. Smoove as guest star. But according to The Hollywood Reporter, Freeform has cancelled their series. Ebanks was to play Grace, Nicki's mother. Production began in January 2016. In October 2016, Minaj stated the filming was postponed. Selita Ebanks will be seen in the MTV's which premieres 17 April 2018.
Ebanks has run her own talent school "Stardom Youth Foundation" since 2004 in her hometown Cayman Islands, providing career guidance for teenagers. She also formed a charity organization, "Women’s Coalition for Empowerment and Opportunity", after a trip to Sierra Leone in 2008. The organization helps to support women’s educational and professional programs in the civil war-torn African nation. She joined the tour in 2013 and 2014 raising more than $1 million for women and childrenall over the world.