STAT2
Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene. It is a member of the STAT protein family.Function
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon, this protein forms a complex with STAT1 and IFN regulatory factor family protein p48, in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.Interactions
STAT2 has been shown to interact with:
