Recurrent corneal erosion


Recurrent corneal erosion is a disorder of the eyes characterized by the failure of the cornea's outermost layer of epithelial cells to attach to the underlying basement membrane. The condition is excruciatingly painful because the loss of these cells results in the exposure of sensitive corneal nerves. This condition can often leave patients with temporary blindness due to extreme light sensitivity.

Signs and symptoms

Symptoms include recurring attacks of severe acute ocular pain, foreign-body sensation, photophobia, and tearing often at the time of awakening or during sleep when the eyelids are rubbed or opened. Signs of the condition include corneal abrasion or localized roughening of the corneal epithelium, sometimes with map-like lines, epithelial dots or microcysts, or fingerprint patterns. An epithelial defect may be present, usually in the inferior interpalpebral zone.

Cause

Most cases of recurrent corneal erosion are acquired. There is often a history of recent corneal injury, but also may be due to corneal dystrophy or corneal disease. In other words, one may suffer from corneal erosions as a result of another disorder, such as map-dot fingerprint dystrophy. Familial corneal erosions occur in dominantly inherited recurrent corneal erosion dystrophy in which COL17A1 gene is mutated.

Diagnosis

The erosion may be seen by an eye doctor using the magnification of a biomicroscope or slit lamp. Usually fluorescein stain must be applied first and a cobalt blue-light used, but may not be necessary if the area of the epithelial defect is large. Optometrists and ophthalmologists have access to the slit lamp microscopes that allow for this more-thorough evaluation under the higher magnification. Mis-diagnosis of a scratched cornea is fairly common, especially in younger patients.

Prevention

Given that episodes tend to occur on awakening and managed by use of good 'wetting agents', approaches to be taken to help prevent episodes include:
; Environmental:
;General personal measures:
;Pre-bed routine:
;Waking options:
With the eye generally profusely watering, the type of tears being produced have little adhesive property. Water or saline eye drops tend therefore to be ineffective. Rather a 'better quality' of tear is required with higher 'wetting ability' and so artificial tears are applied frequently. Also recommended is Muro 128 5% Ointment which is a great relief overnight, it lasts longer than most regular tears and provides protection for those with severe cases.
Nocturnal Lagophthalmos may be an exacerbating factor, in which case using surgical tape to keep the eye closed at night can help.
Whilst individual episodes may settle within a few hours or days, additional episodes will recur at intervals.
Where episodes frequently occur, or there is an underlying disorder, one medical, or three types of surgical curative procedures may be attempted:
use of therapeutic contact lens, controlled puncturing of the surface layer of the eye and laser phototherapeutic keratectomy. These all essentially try to allow the surface epithelium to reestablish with normal binding to the underlying basement membrane, the method chosen depends upon the location & size of the erosion.

Surgical

A punctal plug may be inserted into the tear duct by an optometrist or ophthalmologist, decreasing the removal of natural tears from the affected eye.
The use of contact lenses may help prevent the abrasion during blinking lifting off the surface layer and uses thin lenses that are gas permeable to minimise reduced oxygenation. However they need to be used for between 8–26 weeks and such persistent use both incurs frequent follow-up visits and may increase the risk of infections.
Alternatively, under local anaesthetic, the corneal layer may be gently removed with a fine needle, cauterised or 'spot welding' attempted. The procedures are not guaranteed to work, and in a minority may exacerbate the problem.
Anterior Stromal Puncture with a 20-25 gauge needle is an effective and simple treatment.
An option for minimally invasive and long-term effective therapy is laser phototherapeutic keratectomy. Laser PTK involves the surgical laser treatment of the cornea to selectively ablate cells on the surface layer of the cornea. It is thought that the natural regrowth of cells in the following days are better able to attach to the basement membrane to prevent recurrence of the condition. Laser PTK has been found to be most effective after epithelial debridement for the partial ablation of Bowman's lamella, which performed prior to PTK in the surgical procedure. This is meant to smoothen out the corneal area that the laser PTK will then treat. In some cases, small-spot PTK, which only treats certain areas of the cornea may also be an acceptable alternative.

Medical

People with recalcitrant recurrent corneal erosions often show increased levels of matrix metalloproteinase enzymes.
These enzymes dissolve the basement membrane and fibrils of the hemidesmosomes, which can lead to the separation of the epithelial layer. Treatment with oral tetracycline antibiotics together with a topical corticosteroid, reduce MMP activity and may rapidly resolve and prevent further episodes in cases unresponsive to conventional therapies. Some have now proposed this as the first line therapy after lubricants have failed.
There is a lack of good quality evidence to guide treatment choices. A recently updated Cochrane Review concluded that "Studies included in this review have been of insufficient size and quality to provide firm evidence to inform the development of management guidelines."

Footnotes