In the Roman and Byzantine periods, Qatanna was home to extensive settlement including agricultural institutions, roads, and many burial caves.
Ottoman era
Incorporated into the Ottoman Empire in 1517 with all of Palestine, Qatanna appeared in the 1596 Ottoman tax registers as being in the Nahiya of Quds of the Liwa of Quds. It had a population of 12 households, all Muslim, and paid taxes on wheat, barley, olives, occasional revenues, goats and/or beehives. In 1838 Katunneh was noted as a Muslim village, part of Beni Malik district, located west of Jerusalem. In 1863, the French explorerVictor Guérin found the village to have 250 inhabitants, while an Ottoman village list of about 1870 showed that Kattane had a population of 300, in 57 houses, though the population count included only men. It was also noted that it was located north of Abu Ghosh, in the Beni Malik district. In 1883, the PEF's Survey of Western Palestine described it as a "small village in a deep, narrow, rocky valley, surrounded by fine groves of olives and vegetable gardens." In 1896 the population of Katanne was estimated to be about 351 persons.
British Mandate era
In the 1922 census of Palestine conducted by the British Mandate authorities, Qatanneh had a population 633, all Muslims. In the 1931 census it was counted with Nitaf, together they had 875 Muslim inhabitants, in 233 houses. In the 1945 statistics Qatanna had a population of 1,150, all Muslims, with 9,464 dunams of land, according to an official land and population survey. Of this, 1,829 dunams were plantations and irrigable land, 1,603 used for cereals, while 32 dunams were built-up land.
Since the Six-Day War in 1967, Qatanna has been under Israeli occupation. The population in the 1967 census conducted by the Israeli authorities was 1,594, of whom 151 were refugees. Currently, the town has a total land area of 3,555 dunams, of which 677 dunams are designated as built-up area. After the 1995 Interim Agreement on the West Bank and the Gaza Strip, civil administration of 716 dunams of Qatanna's land was transferred to the Palestinian National Authority. Qatanna contains three schools, three kindergartens, three clinics, a pharmacy and a medical center run by the Palestinian Red Crescent. There is also a sport's club and a women's center in the town. Qatanna is governed by a village council and Ramallah serves as the town's main urban provider. Four springs — al-Balad, as-Samra, an-Nimr and an-Namous — provide water for the town. The latter spring is completely isolated from the town by the Israeli West Bank barrier. 36 dunums were confiscated from Qatanna for the Israeli settlement of Har Adar, built in 1986.