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Pyrimidine analogue
Pyrimidine
analogues
are
nucleoside analog
antimetabolites
which
mimic
the
structure
of
metabolic
pyrimidines
.
Examples
5-Fluorouracil which inhibits
thymidylate synthase
.
Floxuridine
Cytarabine
6-azauracil
gemcitabine
Medical
Uses
Pyrimidine antimetabolites are commonly used to
treat
cancer
by
interfering
with
DNA replication
.