Phlyctenular keratoconjunctivitis


Phlyctenular keratoconjunctivitis,is an inflammatory syndrome caused by a delayed hypersensitivity reaction to one or more antigens. The triggering antigen is usually a bacterial protein, but may also be a virus, fungus, or nematode.

Symptoms

In cases where the cornea is affected, pain and photophobia are more likely, and corneal scarring can occur.

Presentation

The syndrome is marked by the appearance of characteristic lesions, known as phlyctenules, on the cornea and/or conjunctiva. These usually manifest as small raised nodules, pinkish-white or yellow in color, which may ulcerate and are often surrounded by dilated blood vessels. Corneal lesions are usually triangular in shape, with the base at the limbus and the apex pointing towards the center of the cornea.

Diagnosis

Clinical findings of Corneal lesion or corneal ulceration.

Treatment

The symptoms of phlyctenular keratoconjunctivitis are primarily treated with application of an appropriate corticosteroid eye drop, such as prednisolone acetate or loteprednol. Loteprednol is increasingly preferred due to its lower risk of elevating intraocular pressure. The corticosteroid suppresses the immune response, reducing inflammation and improving most symptoms.
The causative agent should also be identified. Staphylococcus aureus is usually the primary suspect, along with Mycobacterium tuberculosis in areas where TB is endemic, followed by Chlamydia trachomatis. Active bacterial infections may be treated with a topical antibiotic or a combination antibiotic-steroid eye drop, such as tobramycin/dexamethasone. An oral tetracycline antibiotic may be used in systemic or particularly severe/intractable infections. Erythromycin may be an effective alternative, especially in pediatric cases where the side effects of tetracyclines are unacceptable.
Artificial tears can reduce dryness and discomfort from corneal lesions. Photophobic discomfort can be mitigated with dark sunglasses.