Pazuzu is the demon of the southwest wind known for bringing famine during dry seasons, and locusts during rainy seasons. Pazuzu was invoked in apotropaic amulets, which combat the powers of his rival, the malicious goddess Lamashtu, who was believed to cause harm to mother and child during childbirth. Although Pazuzu is, himself, considered to be an evil spirit, he drives and frightens away other evil spirits, therefore protecting humans against plagues and misfortunes.
In the 1971 novel The Exorcist and the film based on the novel, Pazuzu is supposedly the evil spirit that possesses the young girlRegan MacNeil. He reappears in the 1977 sequel . In this film, Pazuzu is both named as the demon antagonist of Regan and the unwitting helper of Father Philip Lamont, as he seeks to free Regan from the demon's grip.
William S. Burroughs invokes Pazuzu in the dedication for his novel Cities of the Red Night.
Pazuzu is mentioned in the Simon Necronomicon, a publication of Avon Books that purports to document incantations to invoke "incredible things, beings, and monsters into visible form". He is described therein as "Lord of all fevers and plagues, grinning Dark Angel of the Four Wings, horned, with rotting genitalia", and as the "brother of HUMWAWA". The book claims that he is among the most fearsome of all entities, stating in part: "It is the able magician indeed who can remove PAZUZU once he has laid hold of a man, for PAZUZU lays hold unto death." Although the book makes the claim that Pazuzu was of Sumerian origin, critics John Wisdom Gonce III and Daniel Harms document the erroneous nature of such a claim, stating: "Likewise, the demon Pazuzu does not appear in myth until Assyria's rise in the first millennium B.C., long after Sumer's prime... Thus the beings of the Simon Necronomicon bear little resemblance to either Sumerian myth or Lovecraftian fiction."
Pazuzu is featured in the 2014–15 NBC television series Constantine in a two-part episode "The Saint of Last Resorts". The protagonist, John Constantine, summons Pazuzu to combat Lamashtu, the primary antagonist of the first part, and later willingly allows Pazuzu to possess him to save himself from another powerful demon. However, Pazuzu has no wish to leave his new host, and emerges whenever Constantine is in danger, causing the deaths of at least eight dangerous gangbangers. Luckily, Constantine's ally Anne-Marie is able to exorcise Pazuzu by the end of the second part.
Pazuzu is a character in the 2018 novel On Devil's Wings by M. J. Meade.
The podcast The Black Tapes, episode 108, explores a demon board called the "Zuzu" or Pazuzu board, designed to summon Pazuzu to the human world.
Pazuzu made an appearance in a 2017 episode of The Simpsons, "Treehouse of Horror XXVIII", possessing Homer, Maggie and Bart in a spoof of The Exorcist.