Rodenburg trained in Voice Studies at the Central School of Speech and Drama, and initially worked as an actress before moving into teaching. She has been Head of Voice at the Guildhall School of Music and Drama in London since 1981 and the Director of Voice at Michael Howard Studios in New York since 1982. She worked with the Royal Shakespeare Company for nine years from 1981, and with the Royal National Theatre from 1990, where she founded their Voice Department. She has worked globally with the Moscow Art Theatre, Complicite, Cheek by Jowl, and Comedie-Francaise. She has taught thousands of actors, including Daniel Craig, Orlando Bloom, Joseph Fiennes, Ewan McGregor and Fay Ripley to name a few. She has authored several books on the subject of voice coaching, including "Speaking Shakespeare," "The Actor Speaks," "The Right to Speak," "The Need for Words," and "Second Circle". In 2005, Rodenburg was appointed an Officer of the Order of the British Empire in the Queen's Birthday Honours. In 2006, Rodenburg directed a production of King Lear at the Electric Lodge theatre in Los Angeles. The Los Angeles Times called the production "emotionally potent," and Variety’s critic claimed, "The brilliant cast brings this play to vibrant, painful life." In 2010, Rodenburg was listed at number 15 of The Times newspaper's "The Luvvie Power List 2010," a list of theatre's 50 most influential people, saying Rodenburg "has worked with some of the world's most powerful actors, among them Judi Dench and Ian McKellen." The Board of Directors at VASTA, the Voice And Speech Trainers Association, honored Rodenburg with their Lifetime Distinguished Membership. They cite it as an honor reserved for individuals "who have made outstanding contributions to the field of Voice & Speech." In 2015, Patsy Rodenburg and Michael Howard Studios established The Patsy Rodenburg Center for Voice and Speech. In June 2015, for the first time, Patsy began offering a program to train others in her teaching methods and artistic philosophy: The Patsy Rodenburg Master Teacher Certification Program. This program offers rigorous, personalized training leading to certification as a Registered Rodenburg Teacher. In 2020, VASTA's Voice and Speech Review featured Rodenburg Voice and Speech in their Vocal Traditions Series.
Rodenburg was married to a teacher at the Royal Central school of Speech and Drama, but his alcoholism led to the breakdown of the relationship. She later lived until 2016 with ballet dancer and choreographer Antonia Franceschi and their son Michael Franceschi.
