Paolo Brenner


Paolo Brenner is a German physician and a professor of cardiac surgery at the Dept. of Cardiac Surgery, Klinikum Großhadern of the Ludwig Maximilian University of Munich. He is known for his work in the fields of xenotransplantation, the advancement of artificial hearts, extracorporeal membrane oxygenation and lung transplantation.

Biography

As an adolescent Brenner was engaged as a cofounder of the Deutsche Gesellschaft für Kosmologie. He was editor and co-publisher of the Zeitschrift für Kosmologie 1990-2007. In this function he was driven by his own physical research paper titled The biography of fixed stars and by his work at Jugend forscht about black holes and published several own papers and surveys about cosmological subjects.

Scientific contribution

Since 1993 Brenner deals with topics of thoracic organ transplantation, since 2004 as a transplant surgeon of heart and lung transplantation, since 2006 as a member of the Munich Lung Transplant Group and already since 2000 as an explant surgeon of the German Organ Transplantation Foundation. Yet 1993 he acted as a junior operator of the former Baxter Novacor Company for the wearable artificial heart system Novacor and researched at last as a proctor of JarvikHeart in cooperation with Robert Jarvik developing a new miniaturized “valve axial pump”. Supported by the Bavarian Research Foundation together with his research team as a consultant of cardiac surgery he investigated the xenogeneic transplantation of multi-transgenic pig hearts as a possible future organ replacement therapy in man since 1997. Since 2004 he worked within the scope of a Transregio Research Group FOR 535 of the German Research Foundation and since 2012 as a principal investigator for the sector of xenogeneic heart transplantation of the Transregio Research Collaborative Research Centre 127 with the speaker Bruno Reichart in the Walter-Brendel-Center of experimental medicine.
Cardiac xenotransplantation, which was studied by Brenner and Reichart since 1997, has reached a preclinical status despite of a higher immunological complexity than allotransplantation due to preexisting and new-built antibodies against whole organs. Using a patented combination consisting of transgenic organs/cells and immunoadsorption and a special combination of immunosuppressive drugs hyperacute and delayed xenograft rejection should be prevented and long-term survival of a xenograft should be enabled and realized. In times of massively increasing shortage of donor organs and yet major problems with artificial hearts this makes xenotransplantation highly interesting in the area of organ/cell transplantation. By using an almost unlimited source of porcine organs and cells not only in Europe, but also worldwide many people could be helped with animal cells or with the replacement of a whole organ.
In view of 45 original papers, over 110 national and international oral presentations, two highly prized international research awards and as an advising tutor of 20 postdocs and postgraduates Brenner did pioneer work and substantially contributed to the scientific progress of the LMU, especially due to his know-how in the area of xenotransplantation and mechanical circulatory support systems. Brenner can be classified as an international expert for mechanical and “biological” heart replacement, wherefore he also owns patents. In his teaching activity since 2004 Brenner was involved in the introduction of the practical MECUM student educational program of the LMU oriented to the Harvard-University concept. Since 2007 he was the responsible organizing associate lecturer for the compartment of cardiac surgery of the LMU and since 2011 deputy speaker of the cardiovascular educational block of the new medical student education system Modul 23 of the LMU. As the leader of the cardiac surgical advanced training program he organized about 400 specialist and scientific qualification performances mostly as from the Bayerische Landesärztekammer certificated Monday education for consultant training and professional development since 2003.
Novel research focuses and interests of Brenner are miniaturized artificial hearts in heart valves, inhibition of aging enzymes, cryonic, energy and environment technology, essential oils as well as ebola.

Awards

Medical associations:
Other academic associations
Medical journals:
Other journals:
The community of Neuried elected Brenner as a deputy Chairman of the Christian Social Union in Bavaria in the local council and building- and environment committee. in 2014.