The story begins at Ravanan's abode and the time of Ramayana when he orders his uncle Mareesan to transform into a deer to abduct Seetha. Mareesan argues with Ravana but finally complies since Idumba and Ravana threaten the life of Mareesan's lover Mandahini. Finally, the said thing happens, and Mareesan gets struck by the arrow by lord Rama. He becomes a rock, but not before he transforms Idumba into an anklet and wears it on his leg. Times change, and the modern day comes. Rajaram is a very rich man who owns tea estates. He has Seetha as his dietitian and Sri Rama as his cook. Both Rama and Seetha are in love. On the other hand, Rajaram's relatives plan a plot to take the property. In this process, they end up planning to kill Seetha by pushing her from a mountaintop. Seetha falls directly on the rock idol of Mareesan and gets his human form. At the same time, his anklet falls off and gets eaten by a fish. That fish is caught by fisherman Manickam, and Idumba gets his human form. The age old enmity crops up, and while Mareesan vows to protect Seetha, Idumba plans to help Manickam get Rajaram's property as half brother. What happens from there forms the rest of the story..
Abirami Ramanathan, well-known theatre owner and Managing Director of Abirami Mega Mall, forayed into film production with Panchamirtham. The film's inaugural function was held on 13 July 2008. Director, K. Balachander, KRG, Kalaipuli S Dhanu, Kalaipuli Sekaran, Sarath Kumar, Radha Ravi and Rama Narayanan inaugurated the function, A song sequence with Nasser was filmed during the pooja. Earlier Vivek and Vadivelu was said to be the part of this film but proved untrue. A song featuring Saranya Mohan was shot in Ooty and actress-cum-dance master Gayathri Raghuram choreographed it.
Soundtrack
The soundtrack was composed by Sundar C Babu, and lyrics for all songs were written by Vaali.
Nowrunning wrote: "With so many comedians, this film is a slapstick comedy. With children as its target audience, the film entertains". Indiaglitz wrote: "Panchamirtham is a laugh-riot". Rediff wrote: "Even if it isn't as funny or classy as they had promised, the team does deliver some laughs". Kollywood today wrote: "Panchamirtham is a fantastic treat. But unfortunately, there are whole lot of traces of TV serial and Raju Eeswaran with his knack tactics could’ve dealt with this". Behindwoods wrote: "worth a watch".