OK cells
OK cells are a marsupial cell line used in medical research to model proximal tubule epithelial cells of the kidney.Characteristics
The cell line was derived from the kidney of an adult female North American opossum. Like porcine LLC-PK1 cells, this cell line has the limitation of lacking several enzymes specific to the proximal tubule. Nonetheless, OK cells have been used extensively to study functional interactions between the parathyroid hormone 1 receptor and the sodium-hydrogen exchange regulatory factor 1.OK cells were originally cultured as a source of X chromosomes for studies on X inactivation. They have also served as models for the study of renal dopaminergic physiology, owing to their capacity to produce and degrade dopamine. OK cells are sold under the catalog number CRL-1840 by ATCC.
