Hadjikyriakos-Ghikas was born in Athens in 1906. His father was the admiral Alexandros Hadjikyriakos, and his mother Princess Eleni Ghika. His father During his teen years his family recognised the potential of his talent and arranged for him to study painting withthe artist Parthenis. In 1923 he went to Paris to study French Literature and Aesthetics at the Sorbonne University. During his first months in Paris he participated in an exhibition that took place in the Salon des Indépendants. In 1924 he continued his studies in painting and engraving at the Academie Ranson. In 1927 he had his first exhibition at Gallerie Percier. Picasso himself noticed and commented the works of the young Greek artist. In 1933 he organised in Athens the 4th International Architectural Symposium. In 1934 he arranged another exhibition of his paintings and sculptures in the Gallerie des Cahiers d' Art and in the international exhibitions of Paris and Venice. From 1935 to 1937 he was co-editor of the art magazine3rd Eye. In 1941 he was offered a position in the Architectural School of the National Technical University of Athens. In 1949 he formed, with other artists including Yiannis Moralis, Yannis Tsarouchis, Nikos Nikolaou, Nikos Engonopoulos and Panayiotis Tetsis, the "Armos" art group. In 1950 he was the Greek participant at the Venice Biennale where he exhibited 17 of his paintings. During 1950-1968 he organised twelve exhibitions in Athens, Paris, London, Berlin, Geneva and New York. In 1961 he married Barbara Hutchinson, who had previously been married to Victor Rothschild, 3rd Baron Rothschild and to classicist Rex Warner. In 1973 he became a member of the Athens Academy and in 1986 a member of the Royal Academy in London. He was also a member of the Tiberiana Academy in Rome and was granted the title of Officier des Arts et des Lettres from the French government. In 1988 he had his last exhibition at the Royal Academy of London. His wife, Barbara, died in 1989. He died on September 3, 1994, in Athens. Today in Greece he is celebrated as one of the most important modern Greek painters. His house has been converted to a museum and is being run by the Benaki Museum. In 2018, the British Museum hosted an exhibition which focuses on the friendship of Ghika, the artist John Craxton, and the writer Patrick Leigh Fermor; their shared love of Greece was fundamental to their work.