Mississippi Highway 25 Mississippi Highway 25 runs from I-55 in Jackson, Mississippi to the Tennessee state line north of Iuka . The largely controlled-access part from Jackson to Starkville connects the state capital with the main campus of Mississippi State University .History The 1933 Road Map of Mississippi shows MS 25 running northward from Macon roughly along the 2019 alignment of U.S. Route 45 to Brooksville, then roughly along the 2019 alignment of U.S. Route 45 Alternate through Artesia and West Point to Muldon, where the 2019 alignment continues in a northeasterly direction. As of June 28 , 2006, of continuous four-lane divided highway is open between Starkville, Mississippi , and Jackson, Mississippi. The last leg to open was the, $27-million section from the intersection of Highway 19 north of Louisville, Mississippi , to Noxapater Creek in Winston County . This is one of the culminations of the 1987 Four-Lane Highway Program for improving Mississippi roadways. On May 10 , 2006 the next-to-last leg, a, $23-million section, opened from the Oktibbeha County line west into Winston County. Legally, Mississippi 25 is defined in Mississippi Code Annotated § 65-3-3, as follows: "Begins at or near Jackson, Hinds County , thence in a northeasterly direction to or near Carthage, Louisville and Starkville, thence along U.S. 82 to its intersection with U.S. 45A, thence along U.S. 45A to Muldon, thence to or near Aberdeen, Amory, Smithville, to U.S. 78, thence continuing to Belmont , Dennis, Tishomingo, Iuka and to the Mississippi-Tennessee state line north of Cross Roads , Tishomingo County ."Future All of Highway 25, except for the portion between West Point, Mississippi , and Fulton, Mississippi , will be an at least four-lane divided highway by the mid-2010s, per Mississippi House Bill 725 of the 1998 session.Cities on the route From south to north Jackson, Mississippi Flowood, Mississippi Carthage, Mississippi Louisville, Mississippi Starkville, Mississippi West Point, Mississippi Aberdeen, Mississippi Amory, Mississippi Smithville, Mississippi Fulton, Mississippi Belmont, Mississippi Tishomingo, Mississippi Iuka, Mississippi Major intersections
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