Mir-663 microRNA precursor family


In molecular biology mir-663 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

Gastric cancer suppression

miR-663 has been identified as a possible suppressor of tumour growth, with its levels downregulated in human gastric cancer cell lines. miR-663 introduction into the two human GC cell lines BGC823 and SNU5 induces morphology changes and suppresses cell proliferation. Transfection with miR-663 also sees a resultant upregulation of cyclin B.

miR-155 upregulation and other molecular targets

Resveratrol, a natural phenol and antioxidant, upregulates miR-663 in human THP-1 monocytic cells, human blood monocytes and MCF7 brest cancer cells. Endogenous activator protein-1 activity is decreased by miR-663 and there is additional impaired lipopolysaccharide upregulation. miR-663 directly targets JunD and JunB transcripts, and alters AP-1 upregulation through this. It is further involved in the impaired lipolysaccharide upregulation of miR-155 by resveratrol. miR-663 also directly targets EEF1A2, transaltion elongation factor and well-known protooncogene.