Weber attended Cass Technical High School in Detroit, Michigan. As a senior, he rushed for 2,268 yards with 29 touchdowns, despite missing three games to injury. He averaged 10.1-yards per carry, while helping his team reach the state's semifinals. He rushed for a state record 404 yards and five touchdowns in the regional championship win over Chippewa Valley High School. He was named All-state, U.S. Army All-American and was a co-recipient of the Detroit player of the year award.
College career
Weber originally accepted a football scholarship from the University of Michigan, but changed his decision to enroll at Ohio State University instead. After redshirting his first year in 2015, Weber took over as the starting running back role in 2016, replacing Ezekiel Elliott who had graduated. In his first career game he rushed for 136 yards on 19 carries against Bowling Green State University. He led the team with 1,096 rushing yards on 182 carries and 9 rushing touchdowns in 13 starts. At the end of the season, he was named the Thompson–Randle El Freshman of the Year and second-team All-Big Ten. As a sophomore, he suffered a left hamstring injury during summer workouts that kept him out most of training camp, falling behind on the depth chart behind true freshman J. K. Dobbins. He got healthy in the latter part of the season, finishing with 101 carries for 626 yards and 10 rushing touchdowns in a backup role. As a junior, he was again the backup behind Dobbins, while appearing in 13 games. He registered 172 carries for 954 yards and 6 touchdowns. He switched his jersey number from 25 to 5 for the contest against the University of Michigan, returning to his former number for the team's final two games. On December 16, 2018, Weber announced that he would forgo his final year of eligibility and declared for the 2019 NFL Draft.
On January 8, 2020, Weber was signed to the Kansas City Chiefs practice squad. Weber won Super Bowl LIV with Chiefs after they defeated the San Francisco 49ers 31-20. He re-signed with the Chiefs on February 5, 2020. On May 4, 2020, Weber was waived after running back Clyde Edwards-Helaire was picked by the Chiefs in the first round of the 2020 NFL Draft.
