Zappella graduated in 1960 in Medicine and Surgery in Rome, Italy. He initially relocated to London, where he worked with the Fountain Hospital of London from 1961 to 1963. He then moved back to Rome, where he worked in the medical field and specialized in Pediatrics. As winner of a Fulbright grant for the United States, he became a Fellow of Neurology in the Department of Child Neurology at Children's Hospital in Washington D.C., serving there from 1964 to 1965. In 1966, he moved to Pisa, Italy, where he specialized first in Child Neuropsychiatry and then, in 1968, in Nervous and Mental Diseases. In 1970 he became Lecturer in Mental Health. He was head of the Department of Child Neuropsychiatry of Siena Hospital from 1973 to 2006., he is teaching Child Neuropsychiatry in the Schools of Specialization of the University of Siena and serves as a consultant in the Rett Center of Versilia Hospital in Italy. Zappella is an honorary member of the Society for the Study of Behavioural Phenotypes in London and of the Italian Society of Pedagogy. He was the President of the Italian Society of Tourette's Syndrome from 1999 to 2003, and Vice President of the Italian Society of Child Neuropsychiatry from 1976 to 1978. He has been involved in social integration and education of disabled children. From 1969 through 1970, he was focused on publishing the first papers on this subject. In the 1960s, Zappella studied the Placing Reflex and its connections with the early diagnosis of severe mental retardation. His studies on Rett Syndrome have shown that there is a milder variant of this syndrome in which children acquire late some manual skills and spoken language. This variant is known as the Zappella Variant of Rett Syndrome in the scientific community. Zappella has extensively studied Autistic Disorders, discovering the Dysmaturational Syndrome, which manifests as a transitional autistic behavior, associated with motor and vocal tics, which has a genetic cause Tourette-like, quite different from stable Autistic Disorders. He introduced a form of rehabilitative therapy, known as Emotional Activation through Body Reciprocity. In 1981, in recognition of his studies on Autism, Zappella received the Gold Medal and the Honorary Citizenship of the town of Sesto San Giovanni, Italy.
Zappella, Michele. Le encefalopatie congenite del neonato e del lattante, Infanzia Anormale, 11, 1967.
Zappella, Michele. Il Pesce Bambino, Milano: Feltrinelli, 1976. ; translated in French, l'Enfant Poisson, Paris: Payot, 1979..
Zappella, Michele. Il Bambino nella Luna, Milano: Feltrinelli, 1979..
Zappella, Michele. Non vedo, non sento, non parlo, Milano: Mondadori, 1984; translated in Spanish, No veo, no oigo, no ablo, Paidos Terapia Familial, 1992..
Zappella, Michele. I bambini autistici, l’holding e la famiglia, Roma: Nuova Italia Scientifica, 1987..
A.A.V.V. Metodo Portage, ed. italiana a cura di Michele Zappella, Torino: Omega, 1989..
Zappella, Michele. Autismo Infantile, Roma: Carocci, 1996. ; translated in Spanish, Autismo Infantìl, Instituto de Cultura Economica: Mexico, 1998..
Zappella, Michele; with Dario Ianes. Facciamo il punto su l'autismo, Trento: Erickson, 2009..
