Merrifield resin


Merrifield Resin is a cross-linked polystyrene resin that carries a chloromethyl functional group. Merrifield resin is named after its inventor, Robert Bruce Merrifield, and used in solid-phase synthesis. The material is typically available as white beads. These beads are allowed to swell in suitable solvents, which then allows the reagents to substitute the chloride substituents.
Merrifield Resin can be prepared by chloromethylation of polystyrene or by the copolymerization of styrene and 4-vinylbenzyl chloride.