When a Maid of Honour to the Electress Sophia of Hanover, she became a mistress of the Electoral Prince, George Louis. George Louis succeeded as Elector of Hanover in 1698 and King of Great Britain in 1714. Melusine moved with him to England, and on 18 July 1716 was created for life Duchess of Munster, Marchioness of Dungannon, Countess of Dungannon and Baroness Dundalk, in the Peerage of Ireland. On 19 March 1719 she was further created Duchess of Kendal, Countess of Feversham and Baroness Glastonbury, in the Peerage of Great Britain. In 1723 Charles VI, Holy Roman Emperor, created her Princess of Eberstein. This last creation in particular tended to support the theory that she had married the King in secret. Robert Walpole said of her that she was "as much the queen of England as anyone was". George's wife Sophia had been kept in imprisonment since their divorce in 1694. The Duchess of Kendal was a very thin woman, being known in Germany as "the Scarecrow" and in England as "the Maypole". The Jacobites called her "the Goose," most famously in the taunting Scots ballad Cam Ye O'er Frae France. When in England, she lived principally at Kendal House in Isleworth, Middlesex. She obtained large sums of money by selling public offices and titles; she also sold patent rights, including the privilege of supplying Ireland with a new copper coinage. This she sold to William Wood, a Wolverhampton merchant, who flooded the country with inferior coins, leading Jonathan Swift to write his Drapier's Letters. In political matters she had much influence with the king, and she received £10,000 for procuring the recall of Viscount Bolingbroke from exile. Melusine bore George three illegitimate children:
Anna Luise Sophie von der Schulenburg, Countess of Dölitz, who married Ernest August Philipp von dem Bussche zu Ippenburg.
Luise Sophie and Petronilla Melusina were officially acknowledged as the children of Melusine's sister Gertrud and her husband Friedrich Achaz von der Schulenburg, a kinsman of the sisters who shared their surname. Margarethe Gertrud was officially named von Oeynhausen because she was recognised as the daughter of Melusine's other sister, Sophia Juliane von Oeynhausen.