MatildaJohannaClerk was a medical pioneer and a science educator on the Gold Coast and in West Africa as well as the second Ghanaian woman to become an orthodox medicine-trained physician. The first woman in Ghana and West Africa to attend graduate school and earn a postgraduate diploma, Clerk was also the first Ghanaian woman in any field to be awarded an academic merit scholarship for university education abroad. M. J. Clerk was the fourth West African woman to become a physician after Nigerians, Agnes Yewande Savage, the first West African woman medical doctor and Elizabeth Abimbola Awoliyi in addition to Susan de Graft-Johnson, née Ofori-Atta, Ghana's first woman physician. These pioneering physicians were all early advocates of maternal health, paediatric care and public health in the sub-region. For a long time after independence in 1957, Clerk and Ofori-Atta were the only two women doctors in Ghana. By breaking the glass ceiling in medicine and other institutional barriers to healthcare delivery, they were an inspiration to a generation of post-colonial Ghanaian and West African female doctors at a time the field was still a male monopoly and when the vast majority of women worldwide had very limited access to biomedicine and higher education. Pundits in the male-dominated medical community in that era described Matilda J. Clerk as "the beacon of emancipation of Ghanaian womanhood."
She had her primary and middle school education at Presbyterian schools at Adawso and Aburi respectively. At the Aburi all girls' middle boarding-school Matilda Clerk attended until the end of 1931, the European missionary teachers dubbed her the "Dux of the School." M. J. Clerk matriculated at Achimota School in 1932. She received a Cadbury scholarship in 1934. At Achimota, she obtained a Second Division Teachers’ Preliminary Certificate and Cambridge Senior School Certificate with exemption from London Matriculation. Matilda Clerk was elected the Girls’ School Prefect in her senior year at Achimota. She was also a trained pianist and harpist; as a student, she excelled in sports. Among her interests were embroidery, art and gardening. In 1942, Matilda Clerk became the first Ghanaian woman to complete the intermediate preliminary course in basic medical science, taking advanced courses in physics, chemistry, botany and zoology at Achimota. The British colonial government at that time effectively allowed only male students to participate in the programme. Thus, before the school permitted M. J. Clerk to enroll in the course in 1940, her father had to formally petition the then Governor of the Gold Coast, Arnold Wienholt Hodson for a special waiver. She was the only candidate, male or female, to pass the first preliminary medical baccalaureate examinations known as the 1st M.B., London, in 1942. Based on her superior academic performance, she was awarded a rare medical scholarship by the colonial government to study medicine at the University of Edinburgh from 1944 to 1949. By winning the award, she became the first Ghanaian woman in the annals of history and in any field to secure a scholarship for higher education abroad. At Edinburgh, she was active in the Student Christian Movement and the International Club. The second Ghanaian woman and fifth West African woman to receive a university baccalaureate degree, M. J. Clerk was also the first woman in Ghana and West Africa to pursue postgraduate qualifications at a graduate school when she obtained a diploma in tropical medicine and hygiene in 1950 from the London School of Hygiene and Tropical Medicine, a constituent college of the University of London; she returned to her homeland in January 1951.
In between her teacher training/secondary education and preliminary medical course at Achimota, she was a science teacher at the Wesley Girls' High School from 1938 to 1940. She later taught biology for two years at her alma mater, Achimota School, from 1942 to 1944.
Matilda Clerk died suddenly, aged 68, on 27 December 1984 at her home in Osu, Accra. Her funeral service was held at the Ebenezer Presbyterian Church, Osu; her remains were buried in the church's graveyard, the Basel Mission Cemetery, also in Osu, Accra. The Ghanaian physician, scholar, university administrator and public servant Emmanuel Evans-Anfom delivered the eulogy at her funeral.