MAS1
MAS proto-oncogene, or MAS1 proto-oncogene, G protein-coupled receptor, is a protein that in humans is encoded by the MAS1 gene.
The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects.
Agonists of the receptor include angiotensin-. Antagonist include A-779, or D-Pro.
Mas1 proto-oncogene is not to be confused with the MAS-related G-protein coupled receptor, a recently believed to be activated by the ligand alamandine.
