List of Midwestern cities by size Indianapolis is listed as 2nd largest midwest city when the individual articles show Columbus is larger. In the individual articles Columbus is stated as the 14th largest city Indy is 17th. One of these articles needs to be corrected. Cities in the Midwest with at least 100,000 inhabitants as of July 2017 by the United States Census Bureau: Chicago, Illinois ; 2,722,586 Indianapolis, Indiana ; 853,431 Columbus, Ohio ; 852,144 Detroit, Michigan ; 679,865 Milwaukee, Wisconsin ; 599,086 Kansas City, Missouri ; 476,974 Omaha, Nebraska ; 463,081 Minneapolis, Minnesota ; 411,452 Wichita, Kansas ; 389,054 Cleveland, Ohio ; 388,812 St. Louis , Missouri; 314,867 St. Paul, Minnesota; 300,820 Cincinnati, Ohio ; 298,957 Toledo, Ohio ; 279,455 Lincoln, Nebraska ; 277,315 Fort Wayne, Indiana ; 262,450 Madison, Wisconsin ; 248,856 Des Moines, Iowa ; 214,778 Aurora, Illinois ; 200,946 Grand Rapids, Michigan ; 195,355 Akron, Ohio ; 198,252 Overland Park, Kansas ; 186,147 Sioux Falls, South Dakota ; 170,401 Springfield, Missouri ; 165,785 Kansas City, Kansas ; 151,042 Rockford, Illinois ; 148,640 Joliet, Illinois ; 148,172 Naperville, Illinois ; 146,431 Dayton, Ohio ; 140,939 Warren, Michigan ; 135,147 Olathe, Kansas ; 134,368 Sterling Heights, Michigan ; 131,996 Cedar Rapids, Iowa ; 130,330 Topeka, Kansas ; 127,139 Evansville, Indiana ; 119,806 Ann Arbor, Michigan ; 119,303 Columbia, Missouri ; 118,620 Fargo, North Dakota ; 118,099 Independence, Missouri ; 117,369 Springfield, Illinois ; 116,313 Peoria, Illinois ; 115,424 Lansing, Michigan ; 115,222 Rochester, Minnesota ; 112,683 Elgin, Illinois ; 112,628 Green Bay, Wisconsin ; 104,796 Davenport, Iowa ; 102,268 South Bend, Indiana ; 101,928
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