LMTK2
Serine/threonine-protein kinase LMTK2 also known as Lemur tyrosine kinase 2 is an enzyme that in humans is encoded by the LMTK2 gene.Function
The LMTK2 enzyme belongs to both the protein kinase and the tyrosine kinase families. It contains N-terminus transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as androgen receptor, inhibitor-2, protein phosphatase-1, p35, and myosin VI. It phosphorylates other proteins, and is itself also phosphorylated when interacting with cyclin-dependent kinase 5 /p35 complex. This protein is involved in nerve growth factor -TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis.Loss of LMTK2 has been implicated to play a role in development of prostate cancer.Interactions
LMTK2 has been shown to interact with PPP1CA, Cyclin-dependent kinase 5 and PPP1R2.
