Kodaira was born in Tokyo. He graduated from the University of Tokyo in 1938 with a degree in mathematics and also graduated from the physics department at the University of Tokyo in 1941. During the war years he worked in isolation, but was able to master Hodge theory as it then stood. He obtained his Ph.D. from the University of Tokyo in 1949, with a thesis entitled Harmonic fields in Riemannian manifolds. He was involved in cryptographic work from about 1944, while holding an academic post in Tokyo.
In 1949 he travelled to the Institute for Advanced Study in Princeton, New Jersey at the invitation of Hermann Weyl. He was subsequently also appointed Associate Professor at Princeton University in 1952 and promoted to Professor in 1955. At this time the foundations of Hodge theory were being brought in line with contemporary technique in operator theory. Kodaira rapidly became involved in exploiting the tools it opened up in algebraic geometry, adding sheaf theory as it became available. This work was particularly influential, for example on Friedrich Hirzebruch. In a second research phase, Kodaira wrote a long series of papers in collaboration with Donald C. Spencer, founding the deformation theory of complex structures on manifolds. This gave the possibility of constructions of moduli spaces, since in general such structures depend continuously on parameters. It also identified the sheaf cohomology groups, for the sheaf associated with the holomorphic tangent bundle, that carried the basic data about the dimension of the moduli space, and obstructions to deformations. This theory is still foundational, and also had an influence on the scheme theory of Grothendieck. Spencer then continued this work, applying the techniques to structures other than complex ones, such as G-structures. In a third major part of his work, Kodaira worked again from around 1960 through the classification of algebraic surfaces from the point of view of birational geometry of complex manifolds. This resulted in a typology of seven kinds of two-dimensional compact complex manifolds, recovering the five algebraic types known classically; the other two being non-algebraic. He provided also detailed studies of elliptic fibrations of surfaces over a curve, or in other language elliptic curves over algebraic function fields, a theory whose arithmetic analogue proved important soon afterwards. This work also included a characterisation of K3 surfaces as deformations of quartic surfaces in P4, and the theorem that they form a single diffeomorphism class. Again, this work has proved foundational. .