After the death of Rabbi Sender, his son, Rabbi Yitzchak Eisik Yehuda Yechiel Safrin, was raised by his uncle, Rabbi Tzvi Hirsh Eichenstein of Zidichov. Rabbi Yitzchak Eisik Yehuda Yechiel Safrin of Komarno, known as the Komarno Rebbe, was one of the most prolific expounders of the Teachings of the Baal Shem Tov, producing volumes of original insights on Jewish and Torahphilosophy as inspired by the Baal Shem Tov, whom he calls "Mory V'Rabi", although the Baal Shem Tov died years before his birth. He also wrote insights on the Mishnah and Jewish Law. A hidden Torah Scholar for many years, he only later became known for his genius, piety and ability to work wonders. According to Hasidic legend, he showed a phenomenal ability as a child to foresee events happen before they did. His uncle and foster parent, Rabbi Hirsh of Zidichov, "removed" this talent from him and "hid" it from him to be used at an older more mature age. He was a giant among his generation and although he held positions that were in conflict with the Shulchan Aruch, he never held positions that were not based on the Rishonim and other accepted Talmudic or Zoharsources. Among his other works, Rebbe Yitzchak Eisik of Komarno's monumental commentaries Heichal HaBrachah on the Torah, Otzar HaChaim on the commandments, and Zohar Chai on the Zohar, are classics of Kabbalah as well as Hasidic philosophy.
Rabbi Eisik of Komarno was succeeded as rebbe by his son, Rabbi Eliezer Tzvi Safrin of Komarno. Another son of Rabbi Eisik was Rabbi Alexander Sender Safrin.
* Rabbi Eliezer Zvi was succeeded as rebbe by his son, Rabbi Yaakov Moshe Safrin of Komarno. His son-in-law was Rabbi Chaim Elazar Spira of Munkacs.
**Rabbi Yaakov Moshe was succeeded as rebbe by his son, Rabbi Sholom Safrin of Komarno, a son-in-law of Rabbi Yisrael Perlow of Stolin.
*** Rabbi Sholom was succeeded as rebbe by his son, Rabbi Baruch Safrin. He was the last rebbe to reside in Komarno. He was murdered in the Holocaust together with his whole community.
** Another son of Rabbi Eliezer Zvi was Rabbi Avraham Mordechai Safrin of Borislav.
*** Rabbi Avraham Mordechai was succeeded by his son, Rabbi Chaim Yankev Safrin. Rabbi Chaim Yankev emigrated to the United States before World War II. Rabbi Chaim Yankev was succeeded by his sons,
****Rabbi Sholom Safrin, Komarno rebbe in Jerusalem, Rabbi Sholom Safrin of Jerusalem was succeeded by his sons,
*****Rabbi Netanel Safrin, Komarno rebbe in Jerusalem and
*****Rabbi Eliezer Tzvi Safrin, Komarno rebbe in Beit Shemesh.
****Rabbi Menachem Monish, Komarno rebbe in Bnei Brak, Rabbi Menachem Monish was succeeded by his sons,
*****Rabbi Zvi El'azar, Komarno rebbe in Bnei Brak, and
*****Rabbi Yitzhak Shlomo, Komarno rebbe in Jerusalem.
****Rabbi Alter Yitzchok Elimelech, Komarno rebbe in the United States,
****Rabbi Yissachar Dov Ber, also in Bnei Brak, and
