While still in law school, he was hired by the family of Patty Hearst to assist in the matter of her 1974 kidnapping by the Symbionese Liberation Army. Palladino spent seven years investigating the Peoples Temple tragedy, in which more than 900 members of a religious cult died in Guyana in 1978. His interviews with surviving members of the cult and their families are now part of the definitive history of that event. In 1982, John DeLorean — a former GM executive who had created a struggling independent sports car company — was charged with engaging in a cocaine trafficking deal to fund his company. Palladino & Sutherland interviewed more than two hundred witnesses in a defense which convinced the jury to acquit DeLorean based on entrapment by government agents. Palladino is perhaps best known for being hired by the Bill Clinton presidential election committee to challenge a smear campaign intended to deny Clinton the Democratic nomination. Palladino's work included discrediting women with whom Clinton supposedly had been intimate, according to Newsweek magazine. The Clinton election committee reportedly paid Palladino over $100,000 over several years to "investigate" two dozen women in a "damage control inquiry." Michael Isikoff claimed the Clinton campaign used deception regarding the payments. He says the payouts came from campaign funds, but were listed as legal fees paid to a Denver law firm rather than payments to Palladino. He further claimed that Clinton's chief of staffBetsy Wright later told him the funds were for "controlling Bimbo eruptions." Palladino also was employed by singer Courtney Love to talk to journalists investigating whether she was involved in the 1994 death of her husband, singer Kurt Cobain. Palladino insists he was never involved in "fear and intimidation" in his investigations and production of dossiers on such journalists. When former tobacco executive Jeffrey Wigand began cooperating with 60 Minutes on insider revelations of tobacco company manipulations designed to increase smoker addiction, the industry launched a million dollar public relations campaign to discredit him. Palladino engaged in a counter-investigation that turned the spotlight onto this smear campaign and preserved Wigand's credibility as an expert witness in a lawsuit that subsequently resulted in a more than two hundred billion dollar settlement, in the first successful litigation against Big Tobacco. This effort is chronicled in Marie Brenner's May 1996Vanity Fair article "The Man Who Knew Too Much" and in the 1999 Michael Mann film The Insider in which Palladino appears as himself, and his partner, Sandra Sutherland, is played by actress Megan Odebash. In 2002, singer, songwriter, and record producer R. Kelly was charged with videotaping himself having sex with an underage teenage girl. An investigation by Palladino that lasted six years culminated in Palladino's testimony at trial challenging the principal prosecution witness, and the acquittal of Kelly in less than a day. In April 2009, Australian businessman Peter Holmes à Court admitted in the NSW Supreme Court that the Hollywood actor Russell Crowe had hired Palladino & Sutherland to investigate opposition to the planned takeover of the South Sydney Rabbitohs. Crowe had first gotten to know Palladino and his Australian wife and partner, Sandra Sutherland, when all three worked on the film The Insider. Ronan Farrow reported in November 2017 that Harvey Weinstein had, through the lawyer David Boies, employed the private intelligence agenciesKroll, Black Cube and private investigator Jack Palladino to spy on and influence Weinstein's alleged victims as well as reporters who were investigating Weinstein, so as to prevent his conduct from becoming public. Note: Palladino is often confused with Anthony Pellicano, a Los Angeles-based private investigator whose client list is similarly composed of celebrities.
