Romeus enrolled at the University of Pittsburgh where he is studying sociology. He sat out the 2006 season as on redshirt status. In 2007, he saw action in all 12 games and recorded 41 tackles. He ranked second on the team in tackles for loss with 11.5 and tied for second with four quarterback sacks. In an upset win in the Backyard Brawlrivalry game against West Virginia, he compiled four tackles and recovered one fumble. Romeus also recorded a sack against Pat White for a seven-yard loss on third down, which prevented a West Virginia comeback bid. That season, he was named a College Football News, Football Writers Association of America, The Sporting News, Rivals.com, and Scout.com freshman All-American. In 2008, he recorded 51 tackles, including 26 solo, 15.5 tackles for loss, and 7.5 sacks. Romeus was named to the Second-team All-Big East Conference. He was also named a Rivals.com Second-team All-Big East, Phil Steele's Second-team All-Big East, and College Football News First-team All-Big East. ESPN named him the eighth-best player in the Big East Conference. He was selected as the Big East Co-Defensive Player of the Year along with teammate Mick Williams in 2009. He finished the regular season playing 12 games making 40 tackles and 8 sacks. He also intercepted a pass, forced 2 fumbles, recovered one, broke up four passes, had 11 hurries and blocked a kick. In April 2010, Romeus was placed on the watch list for the upcoming season's Lott Trophy awarded to country's top defensive player. Heading into the 2010 season, Romeus was also listed by the Sporting News as a second-team preseason All-American.
NFL Combine/College Pro Day
Outside of getting his basic measurements – height, weight, arms, and hands – Romeus didn't participate in any of the other activities due to back and knee injuries.
In the 2011 NFL draft, Romeus was selected with the 226th overall pick by the New Orleans Saints. Having been injured in college, he spent his rookie season on the injured reserve list. Romeus was again injured before the start of the 2012 NFL season, and after he cleared waivers, the Saints placed him on the injured reserve list on June 25, 2012. The New Orleans Saints released him on May 23, 2013.
Toronto Argonauts
Romeus was signed by the Toronto Argonauts on May 21, 2014. He was released by the Argonauts on July 24, 2014.