The Great Spirit has at times been conceptualized as an "anthropomorphic celestial deity," a God of creation, history and eternity, who also takes a personal interest in world affairs and might regularly intervene in the lives of human beings. Numerous individuals are held to have been "speakers" for the Great Spirit; persons believed to serve as an earthly mediator responsible for facilitating communication between humans and the Spirit, or the supernatural more generally. Such a speaker is generally considered to have an obligation to preserve the spiritual traditions of their respective lineage. The Great Spirit, by way of spiritual leaders, is looked to for guidance by individuals as well as communities at large. While belief in an entity or entities known as the Great Spirit exists across numerous indigenous American peoples, individual tribes often demonstrate varying degrees of cultural divergence, which in turn correlates with several distinct beliefs regarding humankind's relationship with the Spirit. As such, a variety of stories, parables, fables, and messages exhibiting different, sometimes contradictory themes and plot elements have been attributed to the same figure by otherwise disparate cultures.
Wakan Tanka
Wakȟáŋ Tȟáŋka can be interpreted as the power or the sacredness that resides in everything, resembling some animistic and pantheistic beliefs. This term describes every creature and object as wakȟáŋ or having aspects that are wakȟáŋ. The element Tanka or Tȟáŋka corresponds to "Great" or "large". Prior to the Christianizationof indigenous Americans by European settlers and missionaries, the Lakota used Wakȟáŋ Tȟáŋka to refer to an organization or group of sacred entities whose ways were considered mysterious and beyond human understanding. It was the elaboration on these beliefs that prompted scholarly debate suggesting that the term "Great Mystery" could be a more accurate translation of such a concept than "Great Spirit". Activist Russell Means also promoted the translation "Great Mystery" and the view that Lakota spirituality is not originally monotheistic. Chief Luther Standing Bear of the Lakota Nation put it thusly:
Manitou
Manitou, akin to the Iroquoisorenda, is perceived as the spiritual and fundamental life force by Algonquian peoples. It is believed by practitioners to be omnipresent; manifesting in all things, including organisms, the environment, and events both human-induced and otherwise. Manifestations of Manitou are also believed to be dualistic, and such contrasting instances are known as aashaa monetoo and otshee monetoo respectively. According to legend, when the world was created, the Great Spirit, Aasha Monetoo, gave the land to the indigenous peoples, the Shawnee in particular.
Gitche Manitou
The Anishinaabe culture, descended from the Algonquian-speaking Abenaki and Cree, inherited the Great Spirit tradition of their predecessors. Gitche manitou is an Anishinaabe language word typically interpreted as Great Spirit, the Creator of all things and the Giver of Life, and is sometimes translated as the "Great Mystery". Historically, Anishinaabe people believed in a variety of spirits, whose images were placed near doorways for protection. According to Anishinaabe tradition, Michilimackinac, later named by European settlers as Mackinac Island, in Michigan, was the home of Gitche Manitou, and some Anishinaabeg tribes would make pilgrimages there for rituals devoted to the spirit. Other Anishinaabe names for such a figure, incorporated through the process of syncretism, are Gizhe-manidoo, Wenizhishid-manidoo and Gichi-ojichaag. While Gichi-manidoo and Gichi-ojichaag both mean "Great Spirit", Gichi-manidoo carried the idea of the greater spiritual connectivity while Gichi-ojichaag carried the idea of individual soul's connection to the Gichi-manidoo. Consequently, Christian missionaries often used the term Gichi-ojichaag to refer to the Christian idea of a Holy Spirit.