He was born at Heusden, in the Dutch Republic, studied at Leiden, and in 1611 became Protestant pastor of Vlijmen, whence in 1617 he returned to Heusden. In 1619, he played an influential part in the Synod of Dort, at which he was the youngest delegate. In 1634, Voetius was made professor of theology and Oriental science at the University of Utrecht. Three years later he became pastor of the Utrecht congregation. He was an advocate of a strong form of Calvinism against the Arminians. The city of Utrecht perpetuated his memory by giving his name to the street in which he had lived.
In March 1642, while serving as rector of the University of Utrecht, Voetius persuaded the university's academic senate to issue a formal condemnation of the Cartesian philosophy and its local defender, Henricus Regius. According to the senate's statement, Cartesian philosophy was to be suppressed because:
Descartes countered with a personal attack on Voetius, in a letter to Jacques Dinet, which he made public in the second edition of his Meditations. Voetius was provoked into getting Martin Schoock to produce a book-length assault on Descartes and his work, the Admiranda methodus. Descartes associated the quarrel with the part Voetius was playing with another controversy with Samuel Maresius, who was at least sympathetic to some Cartesian ideas. Legal and diplomatic moves followed ; and Maresius at the University of Groningen was able to extract some admissions from Schoock that were quite damaging to Voetius. In his long letter to Voetius, Descartes mentioned Aristotelianism only twice; by contrast, the topics of theology, faith, and atheism were put on the table hundreds of times. Both Descartes and Voetius acknowledged that the issue they treated was most of all theological. Voetius pursued the faith-seeking-understanding program whereas Descartes repudiated the faith-lacking-understanding project. The primary concern of Voetius was not to preserve Aristotelianism but to keep the biblical truth that, as he put it, was received from orthodox tradition. Descartes insisted that the article of faith did not fall under the regime of human reason because faith was something one could not fully grasp with reason. He argued that whoever embraced the articles of faith for incorrect reasoning would commit a sin no less grave than those who rejected them. What Descartes desperately defended was the autonomy of human reason and its proper use. In his philosophical enterprise, faith seemed to hinder the autonomy and the use of reason. He believed that his method of doubt would provide a firm road toperfect knowledge. Voetius, however, argued that human reason was surrounded by error and sin, so that perfect knowledge was impossible for humans. He maintained that human beings would be able to learn the truth from divine revelation, which was the only principle in the pursuit of truth. Therefore, for Voetius, Cartesianism was primarily confronted with scriptural truth, not with Aristotelianism.