Patrick was the son of a wealthy lumberman Joseph Patrick, who invented the idea of putting numbers on players' uniforms. , Frank Patrick, and Cyclone Taylor while members of the Renfrew Creamery Kings, 1910. While attending McGill University, Patrick played hockey from 1904 to 1908, winning the Queen's Cup championship in 1905 alongside his brother Lester Patrick. In 1907 Patrick moved with the rest of his family to Nelson, British Columbia, where Joseph established a lumber company. Patrick would spend the next several winters there, except for 1909–10 when he and his brother Lester joined the Renfrew Creamery Kings of the newly formed National Hockey Association. Well-regarded nationally as one of the top defenders in hockey, Patrick was paid $2,000 for the season, an extravagant amount at the time. He scored 8 goals in 11 games for Renfrew, though the team failed to win the championship despite having some of the biggest names in the sport.
PCHA
Frank and Lester helped found the Pacific CoastHockey Association. He played for the Vancouver Millionaires of that league from 1911–1918, winning a Stanley Cup in 1915. He also served as PCHA president until 1924. In addition, he was the owner of the Vancouver Amazons women's hockey team.
NHL
In 1926 the WCHA was sold to the NHL, and Patrick retired from hockey. However he returned to the game in 1933 when he became the managing director of the NHL in. Art Ross, manager and coach of the Boston Bruins, asked Patrick to replace him as coach of the Bruins in September, 1934, offering a salary of $10,500. Patrick would coach the team for two seasons, being relieved of the position following the Bruins loss in the 1936 playoffs, amid allegations that he was drunk during the Bruins series against the Toronto Maple Leafs.
Among Patrick's contributions to hockey were the blue line, the penalty shot, the boarding penalty, and the raising of the stick when a goal is scored, which he suggested. He also made a prophecy: "I dream of the day that teams will dress two goaltenders for each game." This became a reality in the NHL in 1964–65.
As early as January 1916, Frank and his brother Lester talked of the formation of a women's league to complement the Pacific Coast Hockey Association. The proposal included teams from Vancouver, Victoria, Portland and Seattle. The league never formed but in January 1917, the Vancouver News-Advertiser reported that wives of the Seattle Metropolitans had assembled a team. In February 1921, Frank announced a women's international championship series that would be played in conjunction with the Pacific Coast Hockey Association.