Lo Giudice made his operatic debut in 1919 as Gastone in La traviata at the opera house in Livorno. In 1920 he sang Dick Johnson in Giacomo Puccini's La fanciulla del West at the opera house in Tortona. In 1922 he made his first appearance at the Teatro di San Carlo as Prince Vasiliy Ivanovich Shuysky in the Naples premiere of Boris Godunov with Sigismondo Zalewsky in the title role. That same year he had a major triumph at the Teatro Costanzi in Rome singing the title role in Umberto Giordano's Andrea Chénier. He made a number of appearances at the Anfiteatro Gangi in Catania in 1922-1923, including Edgardo in Lucia di Lammermoor, Gastone, and Turiddu in Cavalleria rusticana. In 1924 he made his debut at the Teatro Regio in Turin as Romeo in Riccardo Zandonai's Giulietta e Romeo opposite Hina Spani as Giulietta. He returned to that house several times through 1935, singing such roles as Giannetto Malaspini in La cena delle beffe and Pollione in Norma among others. On 7 March 1925 Lo Giudice made his debut at La Scala as Giosta Berling in the world premiere of Zandonai's I cavalieri di Ekebù under the baton of Arturo Toscanini. Toscanini was quite taken with his performance and Lo Giudice was contracted by him frequently for performances at La Scala through the mid-1930s. In 1926 he alternated in the role of Prince Calàf with tenor Miguel Fleta in the original production of Puccini's Turandot, although Fleta had the honor of singing the part for the opera's opening night. Other roles he portrayed at La Scala included Avito in L'amore dei tre re, Dick Johnson, Giannetto Malaspini, and Giuseppe Hagenbach in La Wally among others. Lo Giudice made his first appearance at the Teatro Comunale di Bologna on 21 November 1925 as Giannetto Malaspini to Carmen Melis's Ginerva and Salvatore Baccaloni's Tornaquinci. He returned to that house in 1927 to portray Mateo in Zandonai's Conchita and again in 1928 to sing Dick Johnson to Iva Pacetti's Minnie. In 1926 he made his debut at the Arena di Verona Festival and in 1927 he sang Prince Calàf to Elena Barrigar's Turandot for his first appearance at the Teatro Regio in Parma. He returned to Parma in 1930 to sing Calàf to Patrizia Toldi's Turandot and again in 1938 to portray Eugenio Beauharnais in Italo Brancucci's Fiorella. Lo Giudice returned to the Teatro di San Carlo in 1927 to sing the title role in Arrigo Boito's Nerone with Elena Barrigar as Asteria. He sang again at that house on 4 February 1928 when he portrayed the title role in the world premiere of Zandonai's Giuliano. The following 14 March he made his first appearance at the Teatro dell'Opera di Roma singing the title role in the world premiere of Giuseppe Mulè's Dafni. He sang several roles at the Rome opera house through 1930, including Giuliano and Calàf. He also made his first appearance at the Teatro Donizetti in Bergamo in 1928 as Des Grieux in Puccini's Manon Lescaut. On the international stage, Lo Giudice performed in opera houses in Hungary, Brazil, and Chile during the 1920s and early 1930s. In 1925 he performed at the Royal Opera, London as Pinkerton in Madama Butterfly. He remained active in Italian opera houses up into the mid-1940s. One of his last performances was a portrayal of Andrea Chénier at the Teatro Verdi in Florence in 1944 with Iris Ferriani as Maddalena. After retiring from the stage he taught singing at the Istituto Musicale Vincenzo Bellini in Catania. He died in Catania at the age of 97.
