While Latin and Byzantine Greek texts treated the disease as a generic pestilence, only later did Arabic writers term the condition ṭāʿūn. In Syriac, both bubonic plague and the buboes themselves are called sharʿūṭā. The Chronicle of Seert makes this term synonymous with Arabic ṭāʿūn. Often, however, Syriac writers referred to an outbreak simply as a pestilence or mortality, mawtānā, equivalent to Arabic wabāʾ. In Pseudo-Zacharias Rhetor's Historia Miscellanea, the clarifying combined form mawtānā d sharʿūṭā is found. The Chronicle of 640 of Thomas the Presbyter dates the "first plague" to the year AG 854.
Several sources attest the plague's origins in Africa. According to Jacob of Edessa, the "great plague began in the region of Kush, south of Egypt, in the year AG 853. Evagrius Scholasticus and the Historia Miscellanea also place its origins in Aethiopiaon the border of Egypt. Michael the Syrian, relying on the lost chronicle of John of Ephesus, says that it began in Kush on the border of Egypt and in Himyar. An inscription dated to 543 records how Abraha, the Ethiopian ruler of Himyar, repaired the Maʾrib dam after sickness and death had struck the local community. The Chronicle of Seert records that Aksum was hit by the pandemic. Early Arabic sources record that plague was endemic in Nubia and Abyssinia. The testimony of Procopius, who says that the plague began in Pelusium in the east of the Nile Delta and then spread to Alexandria, is consistent with an introduction from the Red Sea region, possible via ship-borne rats if the Canal of the Pharaohs was still open. The plague could have originated in commercial links with India or in growing Roman religious links with Nubia and Aksum. A link with India is rendered less likely by the fact that the plague arrived in the Roman Empire before arriving in Persia or China, which had closer links with India. According to Peter Sarris, the "geopolitical context of the early sixth century," with an Aksumite–Roman alliance against Himyar and Persia, "was arguably the crucial prerequisite for the transmission of the plague from Africa to Byzantium."
According to the bishop-chronicler of Tours in the late 6th century, Gregory of Tours, there were numerous epidemics of plague in the Kingdom of the Franks after the Justinianic Plague struck label=none and the surrounding region in the late 540s. Various portents were witnessed and to expiate them the inhabitants of affected areas resorted to processions, prayers, and vigils. Gregory records an epidemic in 571 in the Auvergne and in the cities of label=none, label=none, label=none, and label=none. Gregory's description of the plague as causing wounds in the armpit or groin that he described as resembling snakebite and of patients dying delirious within two or three days allow identification of the disease as bubonic plague; the "wounds" are the characteristic buboes. In 582 Gregory of Tours reports an epidemic in label=none. According to him, the majority of the townsfolk at Albi in 584 died of an outbreak of plague. label=none was hit by plague in 588; there the kingGuntram of Francia recommended a strict diet of barley bread and water. Gregory blames a ship arriving from Hispania for being the source of the contagion, and the epidemic recurred several times thereafter. In 590 Gregory records another plague epidemic at label=none and at label=none at the same time as the plague broke out in Rome under Pope Pelagius II.
