He entered Hamilton College in 1845, graduating in 1848. He then spent time at Lane Theological Seminary, Lawrence Scientific School at Harvard, and then Andover Theological Seminary. During those times he taught to get income, but was interested in entering the ministry. He was ordained in 1856. From 1856 to 1859, he was professor of natural science in the New York state normal school at Albany. From 1859 to 1865, he was principal of the preparatory academy of Chester, New York. He became professor of natural history at Antioch College in 1865, and became its president in 1872. A year later, Orton became president of what was then the Ohio Agricultural and Mechanical College, where he also became professor of geology. He resigned the presidency in 1881, but continued as professor of geology until his death. Orton was assistant state geologist of Ohio from 1869 to 1875. He was named state geologist in 1882, and continued in that position until his death in 1899. He was a member of scientific societies, and was president of the state sanitary association of Ohio in 1884–85. He suffered a partially paralyzing stroke in 1891, but continued to work. Orton served for a time on the geological surveys of the United States, of Kentucky, and of Kansas, and was president of the Geological Society of America, and of the American Association for the Advancement of Science. He was essentially an economic geologist, and specialized in the study of oil and gas, developing several well-known theories, notably the “anticlinal theory”, and becoming widely known as an authority on the nature and geological occurrence of these products. Through his marriage to Anna Davenport Torrey, Orton was an uncle of U.S. President and Supreme Court Chief JusticeWilliam Howard Taft and a brother-in-law to Taft's father, U.S. Attorney General and Secretary of WarAlphonso Taft.
Legacy
OSU constructed a geology building in 1893, and named it Orton Hall, in tribute to Orton's seminal contributions. In 1920, his son Edward Orton Jr., the first Chairman of Ceramic Engineering at The Ohio State University, honored his father with the Orton Memorial Library of Geology, inside Orton Hall, for perusing the theories and records of earthly change.