The DuPage Valley Conference was formed prior to the 1975–76 school year. Its charter members were Glenbard North High School, Glenbard South High School, Naperville Central High School, Naperville North High School, West Chicago Community High School, Wheaton Central High School, Wheaton North High School, and Wheaton Warrenville High School. While the conference has typically kept a constant membership of at least six high schools, the actual membership of the Conference has changed since its founding. The conference experienced the first membership change in 1983, when Glenbard East High School left the Des Plaines Valley League and joined the DVC, replacing Wheaton-Warrenville High School, which was closed due to low attendance. The next change came in 1992, when Wheaton Central High School and Wheaton-Warrenville Middle School changed buildings. The high school became known as Wheaton-Warrenville South High School in order to distinguish it from the closed Wheaton-Warrenville; the middle school became Hubble Middle School. After the 1996 school year, Glenbard South High School left the DuPage Valley Conference, citing an inability to be competitive with the larger member schools in the league. The DuPage Valley Conference operated for one year with only seven schools before admitting former Upstate Eight Conference member West Aurora High School in Aurora, Illinois, the first DVC school outside DuPage County. The move reunited West Aurora with former Upstate Eight charter members Naperville Central, and Wheaton-Warrenville South who were then known as Naperville Community, and Wheaton Community in 1963. Effective at the start of the 2013-14 conference season, West ChicagoCommunity High School left the DuPage Valley Conference and joined the Upstate Eight Conference. At the same time Lake Park High School took the vacant space after leaving the Upstate Eight Conference Valley Division. Following suit with West Chicago Community High School, Glenbard East High School and West Aurora High School expressed interest in joining the Upstate Eight Conference. The two schools voted unanimously to accept the invitation to the Upstate Eight Conference starting in the 2014–2015 season. This effectively left the DVC as a 6 member high school conference. Glenbard North High School declined an invite from the Upstate Eight Conference to join. Prior to the 2015–2016 school year, Metea Valley High School, Neuqua Valley High School, and Waubonsie Valley High School, all formerly of the Upstate Eight Conference Valley Division, accepted an invitation to joined the DuPage Valley Conference, bringing the membership to 9 schools. In late 2016, four members of the DVC, Glenbard North High School, Lake Park High School, Wheaton North High School, and Wheaton Warrenville South High School announced that they would be leaving the conference effective at the end of the 2017–18 school year to form a new athletic conference with current Upstate Eight members Batavia High School, Geneva High School, St. Charles East High School, and St. Charles North High School. The conference is now known as the DuKane Conference. The remaining DVC members Metea Valley, Naperville Central, Naperville North, Neuqua Valley, and Waubonsie Valley continued athletic competition in the DVC despite scheduling concerns, particularly for football. DeKalb High School accepted an invitation to join the DVC for the 2019-2020 season following the break-up of the Northern Illinois Big 12 Conference.
Current members
State titles
The conference as a whole, since its founding in 1975, has won 60 IHSA state titles in sports and activities sponsored by the conference.
Baseball: Naperville Central
Basketball : West Aurora
Basketball : Naperville Central
Bowling : Waubonsie Valley
Chess: Naperville North ; West Chicago
Competitive Dance: Naperville North ; Neuqua Valley ; Lake Park
Cross Country : Naperville North
Cross Country : Glenbard North ; Wheaton North ; Naperville North ; Naperville North ; Wheaton North ; Wheaton Warrenville South
Golf : Wheaton Warrenville South
Golf : Naperville North
Gymnastics : Glenbard North ; Naperville North ; Wheaton North/Warrenville South coop
Gymnastics : Glenbard North ; Naperville North
Scholastic Bowl: Wheaton North
Soccer : Naperville North
Soccer : Naperville North ; Waubonsie Valley
Swimming & Diving : Naperville Central ; Naperville North