Donaldson theory
In mathematics, and especially gauge theory, Donaldson theory is the study of the topology of smooth 4-manifolds using moduli spaces of anti-self-dual instantons. It was started by Simon Donaldson who proved Donaldson's theorem restricting the possible quadratic forms on the second cohomology group of a compact simply connected 4-manifold. Important consequences of this theorem include the existence of an Exotic R4 and the failure of the smooth h-cobordism theorem in 4 dimensions. The results of Donaldson theory depend therefore on the manifold having a differential structure, and are largely false for topological 4-manifolds.
Many of the theorems in Donaldson theory can now be proved more easily using Seiberg-Witten theory, though there are a number of open problems remaining in Donaldson theory, such as the Witten conjecture and the Atiyah–Floer conjecture.