Ackner was called to the bar by the Middle Temple in 1945, practising mainly commercial law. He became a Queen's Counsel in 1961, a bencher of Middle Temple in 1965 and was later treasurer in 1984. He came to public notice acting for victims of thalidomide in the late 1960s in their action for damages against the manufacturer of the drug, Distillers, which was settled before trial, and as counsel for the families of the victims at the public inquiry into the Aberfan disaster in 1967, in which he condemned the "callous indifference, incompetence, ignorance and inertia" in the National Coal Board. Ackner proved to be an inspired choice and he remains a local hero in Aberfan, where a bench in the memorial garden bears a plaque in his memory. He subsequently appeared in a number of very public libel actions, including acting for John Bloom, International Herald Tribune, Svetlana Alliluyeva and Lee Kwan Yew and The Spectator. He was elected to the Bar Council in 1957, was treasurer in 1964, vice-chairman in 1966, and chairman in 1968. He was appointed Recorder of Swindon in 1962, and became an Appellate Judge of Jersey and Guernsey in 1967, serving in both offices until he was appointed a High Court Judge of the Queen's Bench in 1971, receiving the customary knighthood. He became a judge of the Commercial Court in 1973, and was promoted to become a Lord Justice of Appeal and was appointed to the Privy Council in 1980. Three years later, in 1983, he became an honorary fellow of Clare College, Cambridge. On 30 January 1986, he was appointed Lord of Appeal in Ordinary, and was made a life peer as Baron Ackner, of Sutton in the County of West Sussex. He joined in the majority in the House of Lords in 1987 in the 3:2 judgment imposing an injunction to prevent The Guardian, The Observer and The Sunday Times newspapers publishing extracts from Peter Wright's book, Spycatcher, saying that failing to impose an injunction would be a "charter for traitors". He also joined in decisions banning broadcasts by the Provisional Irish Republican Army and Sinn Féin and ruled in the R v R case that a man could be convicted of the rape of his wife.
Retirement
He retired as a Law Lord in 1992 but continued to attend the Lords as a crossbencher. He remained active in Bar politics, supporting the traditional division of the legal profession in the UK and opposing the extension of rights of audience to solicitors.