At Wolfram & Hart, Harmony tells Angel that there was a mix-up with a girl named Dana's medication at a psychiatric hospital, and no longer sedated, she broke down her door, killed several people, and escaped. At the hospital, Dr. Rabinaw tells Angel and Spike that Dana had been kidnapped and tortured for months when she was 10, by the man who killed her family. Recently, she gained incredible strength. Angel realizes Dana — like Buffy — is a vampire slayer, activated by the events in the Buffy series finale. Wesley asks Giles to send “his top guy” to take care of Dana, who turns out to be Andrew Wells. He updates the group on how Willowactivated every potential "Slayer of the Vampyrs"; when Wesley wonders how the Slayers will be trained now that the Watcher’s Council is gone, Andrew explains that Giles and some “Sunnydale alum” have been taking care of it. As Spike heads off to look for Dana, Angel follows Lorne's suggestion to visit Dana's childhood home with a psychic. The psychic flashes back to Dana’s abduction and her family’s murder; the smell of molasses and a basement is “where her pain lives,” he says. Meanwhile, Dana goes to the basement of the building where she was held captive, flashing back to her torturer injecting her with various drugs. When she looks up at his face, he is Spike. Andrew catches up with Spike, and updates him on the Scoobies’ activities - Xander is in Africa, Willow and Kennedy are in Brazil, Buffy and Dawn are in Rome, and everyone else is in England. Andrew guesses that Buffy does not know Spike is alive and wonders why he did not tell her. When Spike follows the scent of blood into Dana's trap, Andrew tries unsuccessfully to shoot Dana with a tranquilizer gun. Spike chases Dana to the basement, where she starts repeating what her torturer once said to her. Dana, channeling Nikki, recognizes Spike as William the Bloody. Before he can explain that she is dreaming of other slayers, she injects him with a sedative. At Wolfram and Hart, Fred and the team realize the smell of molasses indicates Dana was held in a distillery, and they send a tactical team to search abandoned distilleries. Back in the basement, Spike awakens to discover that Dana has cut off his hands. She tells Spike he cannot hurt her anymore, but when he insists she is thinking of someone else, she finally remembers who her torturer really was. Angel arrives, tells Dana her real torturer is dead, and knocks her out with a tranquilizer dart. Spike is taken to the hospital to have his hands reattached. Later, Andrew tells Angel because Dana is a slayer, she belongs in the care of the new council. This goes against Angel's intentions to have her treated in his own W&H facilities. Andrew says none of the Scoobies—implicitly emphasizing Buffy, whom he points out, gives him his orders—trust Angel now that he works at Wolfram and Hart. “Don’t fool yourself… we’re not on the same side.” When Angel presses the issue, a group of slayers comes out of hiding and Andrew makes it clear that they will take Dana by force, if necessary. In the end, Dana is taken away with Andrew. Angel visits Spike at the hospital, where Spike admits he has never thought much about what being evil means, he only ever killed for the rush and enjoyment of the act, and he then states that he never once looked his victims in the eye. At this, Angel replies that Angelus could never stop staring into his victims; for him, it was always about the evil of the act. Spike says Dana is like them; someone turned her into a monster. Angel says Dana was an innocent victim and Spike notes that they were innocent victims once, too.
