Colestipol
Colestipol is a bile acid sequestrant used to lower blood cholesterol, specifically low-density lipoprotein. It is also used to reduce stool volume and frequency, and in the treatment of chronic diarrhea.
Like cholestyramine, colestipol works in the gut by trapping bile acids and preventing them from being reabsorbed. This leads to decreased enterohepatic recirculation of bile acids, increased synthesis of new bile acids by the liver from cholesterol, decreased liver cholesterol, increased LDL receptor expression, and decreasing LDL in blood.The following notable side effects may occur:
Colestipol can bind to a number of drugs and nutrients in the gut and inhibit or delay their absorption. Such substances include:
Colestipol is contraindicated in hypertriglyceridemia.Chemistry
Colestipol is a copolymer of diethylenetriamine —or tetraethylenepentamine according to some sources— and epichlorohydrin. The structure drawing shows the DETA moieties in blue and the epichlorohydrin moieties in red.
