Cairo Commercial Historic District

• Citizens Bank, 128 South Broad Street, a Neoclassical Revival building with a vault design
• 115 South Broad Street, a three-story building with paired stone pilasters
• Zebulon Theater, 207 North Broad Street, a two-story, brick building with Art Deco influence
• United States Post Office, 203 North Broad Street, a Stripped Classical building built with funds from the Federal Emergency Administration of Public Works. It has a New Deal mural, "Products of Grady County", by Paul Ludwig Gill.
• Three, one-story brick warehouses on Railroad Avenue
• Cairo Depot, formerly the Atlantic Coastline Depot, which in 1994 was the Cairo Police Station, a stucco-over-masonry building with overhanging eaves, brackets, and a large hipped roof.